Enhancing Slow Wave Sleep in Depression

Part of paid clinical trials in Winston-Salem, North Carolina.

Sponsor
Wake Forest University Health Sciences
Study ID
NCT07143838
Status
Recruiting
Apply to this trial

Conditions

  • Depression - Major Depressive Disorder

Eligibility Criteria

Sex
ALL
Age
40 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Transcranial Electrical Stimulation (TES) — DEVICE
    Using the Sleep WISP device, transcranial electrical stimulation will be delivered during sleep as 0.5 Hz sine wave, 0.5 mA, between frontal (frontopolar and inferior lateral frontal) and posterior (mastoid and occipital) electrodes.

Study Details

The goal of this pilot study is to determine if non-invasive brain stimulation during sleep can increase deep sleep in adults with depression. It will also determine if increased deep sleep improves cognitive performance and mood ratings. Participants will be asked to wear a non-invasive device that records their brain activity and delivers transcranial electrical stimulation during sleep. Participants will also wear an actigraphy watch that measures activity levels throughout the study. In addition, participants will complete several cognitive assessments and mood and sleep questionnaires throughout the study.

Key Dates

Start date
Jun 4, 2026
Status verified
Jul 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
12 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Transcranial Electrical Stimulation (TES)
    All participants will receive transcranial electrical stimulation (TES) during sleep

Primary Outcome Measure

Duration of Stage N3 Sleep [ Time Frame: From baseline to week 3 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wake Forest University Health SciencesWinston-SalemNorth Carolina27104
Ruth Benca, MD PhD
[email protected]
336-716-2911
Caitlin Carroll, PhD
[email protected]
336-716-2440

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By research site
Wake Forest University Health Sciences· Winston-Salem, NC

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