Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. The most actively recruiting conditions are Breast Cancer, Obesity, Heart Failure, Multiple Myeloma — browse the full list or use the filters to match your diagnosis. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .

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2,930 clinical trials

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Planning Actions for Consistent Engagement

for Physical Activity
1 location in Greensboro
Sponsor: University of North Carolina, Greensboro
Sex: All·Age: 60+·Accepts healthy volunteers
Code: NCT07447401·Not Yet Recruiting

IPP Placement & Intracavernosal Block

for Erectile Dysfunction (ED)
1 location in Winston-Salem
Sponsor: Wake Forest University Health Sciences
Sex: Male·Age: 21+
Code: NCT07246642·Phase 4·Not Yet Recruiting

Marine Lipids Ease Painful TMD

for Temporomandibular Disorder (TMD)
1 location in Chapel Hill
Sponsor: University of North Carolina, Chapel Hill
Sex: All·Age: 18+
Code: NCT07437313·Not Yet Recruiting

About research studies in North Carolina

North Carolina has approximately 2,930 recruiting research studies across a wide range of therapeutic areas. North Carolina hosts Duke University Medical Center, UNC Health, and Wake Forest Baptist Health, with strong programs in oncology, cardiovascular disease, and translational research anchored by Research Triangle Park.

Common conditions studied in North Carolina

  • Breast Cancer (64 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
  • Cancer (44 active studies). Recruiting Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
  • Obesity (42 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
  • Heart Failure (40 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
  • Multiple Myeloma (37 active studies). Recruiting Multiple Myeloma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
  • Endometrial Cancer (25 active studies). Recruiting Endometrial Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.

Leading research sponsors in North Carolina

  • Duke University
  • Wake Forest University Health Sciences
  • University of North Carolina, Chapel Hill
  • UNC Lineberger Comprehensive Cancer Center
  • National Cancer Institute (NCI)

Local regulations and guidelines

Clinical trials in North Carolina are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. North Carolina research additionally follows state public health department oversight and any applicable state privacy statutes.

Compensation & what to expect

How payment typically works
Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
Healthy volunteers
Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in North Carolina. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
What's included beyond payment
Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
Travel and time
Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
Asking about compensation
Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.

How to find a clinical trial in North Carolina

Hipa.ai aggregates every recruiting study in North Carolina from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.

Frequently asked questions

How many paid clinical trials are currently recruiting in North Carolina?

There are approximately 2,930 recruiting clinical trials in North Carolina listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.

Do clinical trials in North Carolina pay participants?

Most recruiting trials in North Carolina compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.

Who can participate in a clinical trial in North Carolina?

Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.

What conditions are most commonly studied in North Carolina?

The most common conditions under active study in North Carolina include Breast Cancer (64), Cancer (44), Obesity (42), Heart Failure (40), among many others. Browse the list above to explore every recruiting trial.

Are there clinical trials for healthy volunteers in North Carolina?

Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in North Carolina on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.

How do I enroll in a clinical trial in North Carolina?

Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.

Browse more clinical trials

All cities in North Carolina

Durham, NC(1,085)Chapel Hill, NC(729)Winston-Salem, NC(585)Charlotte, NC(557)Raleigh, NC(205)Greenville, NC(156)Greensboro, NC(118)Wilmington, NC(109)Asheville, NC(101)Huntersville, NC(82)Cary, NC(65)Pinehurst, NC(60)Morehead City, NC(54)Monroe, NC(51)Fayetteville, NC(43)Jacksonville, NC(39)Gastonia, NC(37)Goldsboro, NC(36)Statesville, NC(36)Concord, NC(34)Hendersonville, NC(34)Salisbury, NC(34)Morrisville, NC(33)Shelby, NC(30)Clinton, NC(29)New Bern, NC(27)Hickory, NC(25)High Point, NC(24)Matthews, NC(24)Clemmons, NC(20)Kinston, NC(20)Hillsborough, NC(19)Research Triangle Park, NC(19)Asheboro, NC(18)Kernersville, NC(17)Mooresville, NC(17)Mount Airy, NC(17)Burlington, NC(16)Reidsville, NC(16)Wake Forest, NC(16)Albemarle, NC(13)Thomasville, NC(13)Garner, NC(12)Denver, NC(11)Wilson, NC(11)Rocky Mount, NC(10)Forest City, NC(9)Lincolnton, NC(9)North Wilkesboro, NC(9)Fort Bragg, NC(8)Kannapolis, NC(8)Carrboro, NC(7)Leland, NC(7)Clyde, NC(6)Kenansville, NC(6)Lenoir, NC(6)Richlands, NC(6)Weaverville, NC(6)Wilkesboro, NC(6)Smithfield, NC(5)Kings Mountain, NC(4)Sanford, NC(4)Washington, NC(4)Fort Liberty, NC(3)Henderson, NC(3)Lumberton, NC(3)Marine Corps Base Camp Lejeune, NC(3)Mebane, NC(3)Oxford, NC(3)Stateville, NC(3)Ahoskie, NC(2)Apex, NC(2)Bermuda Run, NC(2)Charleston, NC(2)Fuquay-Varina, NC(2)Morganton, NC(2)Nags Head, NC(2)Arden, NC(1)Belmont, NC(1)Beulaville, NC(1)Bolivia, NC(1)Boone, NC(1)Clayton, NC(1)Cullowhee, NC(1)Edenton, NC(1)Elizabeth City, NC(1)Graham, NC(1)Huntsville, NC(1)Laurinburg, NC(1)Lexington, NC(1)Mocksville, NC(1)Multiple Locations, NC(1)Murphy, NC(1)New London, NC(1)Pembroke, NC(1)Roanoke Rapids, NC(1)Rose Hill, NC(1)Roxboro, NC(1)Rutherfordton, NC(1)Salem, NC(1)Seymour-Johnson Air Force Base, NC(1)Southern Pines, NC(1)Supply, NC(1)Waynesville, NC(1)

Related healthcare resources in North Carolina

Behavioral health news in North CarolinaLatest North Carolina clinical trials research report

Trials by condition in North Carolina

Breast Cancer· 64Obesity· 42Heart Failure· 40Multiple Myeloma· 37Endometrial Cancer· 25Hypertension· 24Prostate Cancer· 23