Ameliorating Stroke-induced Hemianopia Via Multisensory Training

Part of paid clinical trials in Winston-Salem, North Carolina.

Sponsor
Wake Forest University Health Sciences
Study ID
NCT05894434
Status
Not Yet Recruiting

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Conditions

  • Cortical Blindness, Unspecified Side of Brain
  • Hemianopia, Homonymous

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Multisensory Training — BEHAVIORAL
    The procedure involves repeatedly presenting identical visual-auditory stimuli at a single location in the hemianopic field (initially at 45° of eccentricity along the azimuth) while the patient maintains central fixation (0°, 0°). The visual (a 500 ms flash) and auditory (500 ms broadband noise burst) stimuli are in spatial and temporal congruence.
  • Unisensory Training — BEHAVIORAL
    The procedure involves repeatedly presenting identical auditory stimuli (500 ms broadband noise burst) at a single location in the hemianopic field (initially at 45° of eccentricity along the azimuth) while the patient maintains central fixation (0°, 0°).

Study Details

This study seeks to determine the extent of the visual capabilities that can be restored in hemianopic stroke patients by a multisensory training technique and evaluate changes in the brain that the training induces. The effectiveness of the technique will be evaluated in two interventional contexts: patients whose blindness is long-standing and stable, and another in which intervention is as soon as possible after the stroke.

Key Dates

Start date
Aug 31, 2026
Status verified
Feb 2026
Primary completion
Jul 31, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
72 participants (estimated)
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Standard Intervention: Multisensory Training
    Patients with stable hemianopia (\>6 months) are given multisensory training
  • Active Comparator: Standard Intervention: Unisensory Training
    Patients with stable hemianopia (\>6 months) are given auditory training and crossover to multisensory training
  • Experimental: Early Intervention: Multisensory Training
    Patients with early hemianopia (\<1 months) are given multisensory training
  • Active Comparator: Early Intervention: Unisensory Training
    Patients with early hemianopia (\<1 months) are given auditory training and crossover to multisensory training

Primary Outcome Measure

Clinical Ophthalmological Test Scores [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Wake Forest University School of MedicineWinston-SalemNorth Carolina27157
Benjamin A Rowland, PhD
[email protected]
336-716-7096
Benjamin A Rowland, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Wake Forest University School of Medicine· Winston-Salem, NC

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