Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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Improving the Quality of Care for Asthma Patients at Risk of Exacerbations

for Asthma

6 locations incl. New Haven

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT06596512·Not Yet Recruiting

Mechanistic Assessment of Norepinephrine Therapy vs. Angiotensin-II in Septic Shock

for Septic Shock

2 locations incl. Boston

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06746753·Phase 4·Not Yet Recruiting

A Study to Evaluate the Efficacy and Safety of CBL-514 Injection for Reducing Subcutaneous Fat

for Subcutaneous Fat

Drug: CBL-514

11 locations incl. Encinitas

Sponsor: Caliway Biopharmaceuticals Co., Ltd.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07140939·Phase 3·Not Yet Recruiting

Allograft vs. Autograft Nonunion

for Nonunion Fracture

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07310082·Not Yet Recruiting

Building Relationship, Improving Dialogue, and Growing Empathy (BRIDGE): An Intervention to Support Decision Making for Critically Ill Children

for Decision Making

3 locations incl. San Francisco

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT07390773·Not Yet Recruiting

Assessing Psoriasis Treatment Outcomes

for Psoriasis

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07391423·Not Yet Recruiting

Artificial Intelligence (AI)-Enhanced Pretreatment Peer-review Process to Improve Patient Safety in Radiation Oncology

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07463833·Not Yet Recruiting

SURGIMEDIA: Utilization of Multimedia for Enhanced Surgical Consent

for Pancreas Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07494994·Not Yet Recruiting

Thermal Preconditioning in Mastectomy Patients With Immediate Breast Reduction

for Breast Reconstruction After Mastectomy

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07516483·Not Yet Recruiting

Suzetrigine Frame Trial Comparing Suzetrigine and Acetaminophen

for Analgesic Efficacy

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 21+

Code: NCT07525219·Phase 3·Not Yet Recruiting

Study on Treatment Outcome Patterns for Patients With CLL After Discontinuation of BTK Inhibitors

for Chronic Lymphocytic Leukemia

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07526597·Phase 2·Not Yet Recruiting

Poly-L-Lactic Acid for Vulvovaginal Tissue Regeneration

for Pelvic Organ Prolapse (POP)

1 location in Durham

Sponsor: Cassandra Kisby

Sex: Female·Age: 21+

Code: NCT07544667·Not Yet Recruiting

A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis

for EoE

Drug: Upadacitinib

2 locations incl. Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 65

Code: NCT07588568·Phase 2·Not Yet Recruiting

Tiprelestat Versus Placebo When Added to Standard of Care for the Treatment of Pulmonary Arterial Hypertension (PAH)

for Pulmonary Arterial Hypertension (PAH)

10 locations incl. Tucson

Sponsor: Stanford University

Sex: All·Age: 18 - 75

Code: NCT07601295·Phase 2·Not Yet Recruiting

Revumenib, Azacitidine, and VENetoclax in Newly Diagnosed KMT2A-Rearranged AML

for Leukemia Acute Myeloid

Drug: Venetoclax

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 65

Code: NCT07605949·Phase 2·Not Yet Recruiting

Optimizing PreTerm Infant Ampicillin Dosing

for Early Onset Sepsis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 Days - 7 Days

Code: NCT07610486·Phase 1, Phase 2·Not Yet Recruiting

Pilot Feasibility Study With Doulas

for Post Partum

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: All ages

Code: NCT07614789·Not Yet Recruiting

Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2)

for Aneurysmal Subarachnoid Hemorrhage

2 locations incl. Durham

Sponsor: Dr David Hasan, M.D.

Sex: All·Age: 18 - 85

Code: NCT07493577·Phase 1, Phase 2·Not Yet Recruiting

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

for Solid Tumors

18 locations incl. San Francisco

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07492680·Phase 2·Not Yet Recruiting

Exercise-based Frailty Intervention in Lung Transplantation (XFIT)

for Frailty

4 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18 - 75

Code: NCT06960421·Not Yet Recruiting

A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia

for Pulmonary Hypertension

11 locations incl. Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06327373·Phase 1, Phase 2·Not Yet Recruiting

Liposomal Amphotericin B and Flucytosine Antifungal Strategy for Talaromycosis (LAmB-FAST)

for Talaromycosis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06525389·Phase 3·Not Yet Recruiting

Robotic OCT for ER Anterior Eye Exams

for Develop and Test Robotically Assisted Imaging System for the Front of the Eye

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06566339·Not Yet Recruiting

The PharmFIT Study

for Colorectal Cancer

2 locations incl. Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06656936·Not Yet Recruiting

Food DNA Digestion

for Digestion Rate

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06687226·Not Yet Recruiting

NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings

for HIV Infections

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06854029·Phase 4·Not Yet Recruiting

Varenicline for Smoking Reduction in Veterans Not Ready To Quit

for Veterans

4 locations incl. San Diego

Sponsor: VA Office of Research and Development

Sex: All·Age: 21+

Code: NCT06966362·Phase 4·Not Yet Recruiting

Boosting Exercise Adherence in Knee Osteoarthritis

for Osteoarthritis, Knee

1 location in Durham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07219732·Not Yet Recruiting

A New Way to Share Radiation Therapy Plans Between Doctors, CORRECT Trial

for Lung Carcinoma

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07282444·Not Yet Recruiting

Efficacy of Integrating Next Generation Sequencing for Treatment of Surgical Site Infection After Fracture Fixation:

for Next Generation Sequencing (NGS)

18 locations incl. Tuscaloosa

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 84

Code: NCT07458230·Phase 3·Not Yet Recruiting

A Prospective Registry Study of Patients With Hypertension

for Hypertension (HTN)

2 locations incl. Palo Alto

Sponsor: Vivek Bhalla

Sex: All·Age: 18+

Code: NCT07579260·Not Yet Recruiting

A Widely Inclusive, Hybrid-Decentralized Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALS

for Amyotrophic Lateral Sclerosis ALS

2 locations incl. Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07589764·Phase 1·Not Yet Recruiting

Augmentation Cystoplasty Using an Autologous Neo-Bladder Construct

for Contracted Bladder

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 60

Code: NCT05054790·Phase 2·Not Yet Recruiting

PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma

for Diffuse Midline Glioma

Drug: Nivolumab

3 locations incl. St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 4 - 25

Code: NCT06639607·Phase 1, Phase 2·Not Yet Recruiting

Pharmacogenomic Testing in Pediatric Hematology/Oncology Patients

for Pediatric Cancer

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: Up to 26

Code: NCT06744712·Not Yet Recruiting

Continuous Glucose Monitoring in Patients Undergoing Cardiopulmonary Bypass

for Glucose Metabolism Disorders (Including Diabetes Mellitus)

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06861881·Not Yet Recruiting

Pre-malignant States to Hematologic Malignancies in Firefighters

for Clonal Hematopoiesis of Indeterminate Potential

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 40 - 49·Accepts healthy volunteers

Code: NCT06870760·Recruiting

Apply to this trial

Evaluating a Digital Intervention to Improve Adolescent Condom Use and Communication

for Condomless Sex

1 location in Greensboro

Sponsor: North Carolina Agriculture & Technical State University

Sex: All·Age: 14 - 17·Accepts healthy volunteers

Code: NCT06878755·Not Yet Recruiting

Optimizing Health Related Quality of Life Measurement in Adolescent and Young Adult Oncology

for Malignant Solid Neoplasm

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 15+·Accepts healthy volunteers

Code: NCT06897137·Recruiting

Apply to this trial

Evaluation of Hyivy Floora in Managing Interstitial Cystitis/Bladder Pain Syndrome/High-tone Pelvic Floor Dysfunction

for Interstitial Cystitis/Painful Bladder Syndrome

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18 - 80

Code: NCT07038512·Not Yet Recruiting