A Study of Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Part of paid clinical trials in Cullman, Alabama.

Sponsor
Verdiva Bio Dev Limited
Study ID
NCT07553299
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • VRB-101 — DRUG
    VRB-101 tablets will be administered orally.
  • Placebo — DRUG
    Placebo tablets will be administered orally.

Study Details

The purpose of this study is to identify the weekly oral dose of VRB-101 (oral ecnoglutide) that can effectively maintain body weight in participants with a history of obesity or overweight with weight-related comorbidities.

Key Dates

Start date
Jun 30, 2026
Status verified
Jun 2026
Primary completion
Nov 30, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: VRB-101 (Active Arm 1)
    Participants will receive VRB-101 once every week.
  • Experimental: VRB-101 (Active Arm 2)
    Participants will receive VRB-101 once every week.
  • Experimental: VRB-101 (Active Arm 3)
    Participants will receive VRB-101 once every week.
  • Placebo Comparator: Placebo
    Participants will receive matching placebo to VRB-101 once every week.

Primary Outcome Measure

To identify the dose of VRB-101 for weight maintenance [ Time Frame: Baseline to End of Treatment (Week 17) ]

Central Contacts

Locations (17)

FacilityCityStateZIPSite coordinators
Clinical Study Site 202CullmanAlabama35055-
Clinical Study Site 203PhoenixArizona85028-
Clinical Study Site 212TempeArizona85281-
Clinical Study Site 201Little RockArkansas72205-
Clinical Study Site 214Santa MariaCalifornia93454-
Clinical Study Site 216StamfordConnecticut06905-
Clinical Study Site 204BradentonFlorida34209-
Clinical Study Site 215St. PetersburgFlorida33704-
Clinical Study Site 213El DoradoKansas67042-
Clinical Study Site 210PetalMississippi39465-
Clinical Study Site 205BuffaloNew York14217-
Clinical Study Site 206LenoirNorth Carolina28645-
Clinical Study Site 209JacksonTennessee38305-
Clinical Study Site 211HoustonTexas77040-
Clinical Study Site 217HoustonTexas77008-
Clinical Study Site 218IrvingTexas75063-
Clinical Study Site 207RichmondVirginia23226-

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