A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Conditions

• Obesity
• Overweight

Eligibility Criteria

Sex

ALL

Age

18 Years - 75 Years

Healthy Volunteers

Not accepted

Interventions

• Macupatide — DRUG
  Administered SC
• Eloralintide — DRUG
  Administered SC
• Placebo — DRUG
  Administered SC

Study Details

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

Key Dates

Start date

Jun 30, 2026

Status verified

Jun 2026

Primary completion

Sep 30, 2027

Completion

Feb 29, 2028

Study Design

Enrollment

400 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Macupatide Dose 1
  Participants will receive macupatide subcutaneously (SC)
• Experimental: Eloralintide Dose 1
  Participants will receive eloralintide SC
• Experimental: Macupatide Dose 1 + Eloralintide Dose 1
  Participants will receive macupatide SC and eloralintide SC
• Experimental: Eloralintide Dose 2
  Participants will receive eloralintide SC
• Experimental: Macupatide Dose 1 + Eloralintide Dose 2
  Participants will receive macupatide SC and eloralintide SC
• Experimental: Eloralintide Dose 3
  Participants will receive eloralintide SC
• Experimental: Macupatide Dose 2 + Eloralintide Dose 3
  Participants will receive macupatide SC and eloralintide SC
• Placebo Comparator: Placebo
  Participants will receive placebo SC

Primary Outcome Measure

Percent Change from Baseline in Body Weight [ Time Frame: Baseline, Week 36 ]

Central Contacts

• Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  317-615-4559
  [email protected]
• Physicians interested in becoming principal investigators please contact
  [email protected]

Locations (40)

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