ESP Blocks for Posterior Spinal Fusion

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT07228039
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Postoperative Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • ESP Block with Bupivacaine — DRUG
    Cervical and lumbar ESP blocks performed under ultrasound guidance using plain bupivacaine.
  • ESP Block with Bupivacaine + Liposomal Bupivacaine — DRUG
    Cervical and lumbar ESP blocks performed under ultrasound guidance using bupivacaine admixed with liposomal bupivacaine.

Study Details

This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervical or lumbar posterior spinal fusion. Patients will receive either 0.5% bupivacaine plus liposomal bupivacaine or 0.5% plain bupivacaine. Outcomes include opioid consumption over 72 hours, pain scores, length of stay, and time to ambulation.

Key Dates

Start date
May 31, 2026
Status verified
Nov 2025
Primary completion
Jan 31, 2028
Completion
Jan 31, 2028

Study Design

Enrollment
75 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: ESP + Liposomal Bupivacaine
    Group 1 receives ESP block with 0.5% bupivacaine plus liposomal bupivacaine.
  • Experimental: ESP + Plain Bupivacaine
    Group 2 receives ESP block with 0.5% plain bupivacaine.

Primary Outcome Measure

Postoperative Pain as measured by opiate consumption [ Time Frame: 72 hours ]

Locations (1)

FacilityCityStateZIPSite coordinators
Duke UniversityDurhamNorth Carolina27710-

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By research site
Duke University· Durham, NC

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