Blast Overpressure Longitudinal Study

Conditions

• Low-level Blast Exposure

Eligibility Criteria

Sex

ALL

Age

18 Years - 50 Years

Healthy Volunteers

Accepted

Study Details

The goal of this observational study is to learn about the impact of low-level blast exposure in U.S. Special Operations Forces personnel. The main questions it aims to answer are: What advanced brain imaging changes are related to clinical presentation after low-level blast exposure? What are the relationships between low-level blast exposure and common groups of symptoms after concussion? Participants will: * Undergo advanced brain imaging * Answer questionnaires * Complete clinical tests * Provide blood, urine, and saliva samples * Wear blast sensors

Key Dates

Start date

May 31, 2026

Status verified

Mar 2026

Primary completion

Aug 31, 2030

Completion

Aug 31, 2030

Study Design

Enrollment

250 participants (estimated)

Arms

• Arm: High exposure (experimental)
  Special Operations Forces personnel with higher occupational blast overpressure exposure as measured by blast sensor(s)
• Arm: Low/No exposure (control)
  Special Operations Forces personnel with lower occupational blast overpressure exposure as measured by blast sensor(s)

Primary Outcome Measure

Effective axonal radii mapping [ Time Frame: At baseline and annually through study completion, an average of 5 years ]

Central Contacts

• Tony T Yuan, PhD
  214-808-8971
  [email protected]
• Carrie W Hoppes, PhD
  571-212-4660
  [email protected]

Locations (3)

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