Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

for Pneumococcal Disease

58 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 42 Days - 211 Days·Accepts healthy volunteers

Code: NCT07629440·Phase 3·Recruiting

Apply to this trial

Perceptions of Proposed Warnings for Cannabis Edibles Packaging

for Cannabis Use

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07496489·Enrolling By Invitation

Stress and Menstrual Health

for Menstrual Dysfunction

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07566260·Recruiting

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Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

for Recurrent Chronic Lymphocytic Leukemia

7 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061951·Phase 2·Recruiting

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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

for Obesity

Drug: Semaglutide

99 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07564414·Phase 3·Recruiting

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A Study to Evaluate Axatilimab Versus Best Available Therapy in Pediatric Participants With Chronic Graft-Versus-Host Disease After at Least 2 Prior Lines of Systemic Therapy (AGAVE-256)

for Chronic Graft-versus-host-disease

11 locations incl. Duarte

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 17

Code: NCT07124078·Phase 2·Recruiting

Apply to this trial

'Eat Well' Produce Prescription RCT

for Hypertension

1 location in Durham

Sponsor: Institute for Medical Research, Inc.

Sex: All·Age: 18+

Code: NCT07534501·Recruiting

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Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

for Major Depressive Disorder

25 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT06705478·Phase 2·Recruiting

Apply to this trial

Incorporating Biometric Data for Patients Receiving Concurrent Chemotherapy & RT

for Cancer

1 location in Wilmington

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05937659·Not Yet Recruiting

Adding Asciminib to Usual Treatment for Adults With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia

for Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

8 locations incl. Orange

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 60+

Code: NCT06773936·Phase 2·Enrolling By Invitation

A Study of VIRTUGUIDE System and DePuy Synthes Lapidus Implant in Participants Undergoing Lapidus Procedure

for Hallux Valgus

8 locations incl. Morrison

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 22+

Code: NCT07567092·Not Yet Recruiting

A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence

for Narcolepsy Type 1

2 locations incl. Huntersville

Sponsor: Centessa Pharmaceuticals (UK) Limited

Sex: All·Age: 18 - 70

Code: NCT07598708·Phase 2, Phase 3·Recruiting

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AtraUmatic Laparoscopic HerNia Repair Clinical Investigation to Evaluate the Safety and Performance of The ECLIPSIUM System for Mesh Fixation IDE

for Hernia

12 locations incl. Loma Linda

Sponsor: Tissium

Sex: All·Age: 22+

Code: NCT07277946·Recruiting

Apply to this trial

A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated

for Diabetic Macular Edema

30 locations incl. Phoenix

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07553429·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers

for Smoking

7 locations incl. Maitland

Sponsor: RAI Services Company

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT07598136·Recruiting

Apply to this trial

Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

for Locally Advanced Pancreatic Adenocarcinoma

274 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06998940·Phase 3·Recruiting

Apply to this trial

CAPTURE-2: Controlled Arterial Protection to Ultimately Remove Embolic Material

for Aortic Valve Stenosis

2 locations incl. New Orleans

Sponsor: EmStop Inc

Sex: All·Age: 22+

Code: NCT07276711·Recruiting

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Study of INCA036978 in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

Drug: INCA036978

22 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07441694·Phase 1·Recruiting

Apply to this trial

Family Building Decision Support for Female Adolescent and Young Adult Cancer Survivors

for Cancer Survivorship

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 39

Code: NCT07471685·Recruiting

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An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

for Cardiovascular Disease and Lipoprotein(a)

Drug: Pelacarsen

115 locations incl. Andalusia

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07517263·Phase 3·Recruiting

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A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

for Obesity

Drug: NNC0487-0111

202 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07567001·Phase 3·Not Yet Recruiting

Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

for Obesity or Overweight

39 locations incl. Pelham

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07575399·Phase 3·Recruiting

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A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

for Overweight

48 locations incl. Chandler

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07575932·Phase 2·Recruiting

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A Phase 2 Trial of Dotinurad in Xanthine Oxidase Inhibitor (XOI) Intolerant/Uricase Failure Gout Participants

for Gout

Drug: Dotinurad

17 locations incl. Granada Hills

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07535034·Phase 2·Recruiting

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Effectiveness of Virtual Reality (VR) in the Management of Anxiety for Patients Undergoing Radiotherapy

for Radiation Therapy

1 location in High Point

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07324577·Recruiting

Apply to this trial

An Open-label Extension Safety and Efficacy Study of QCZ484 in Hypertensive Patients.

for Hypertension (HTN)

Drug: QCZ484

6 locations incl. Garden Grove

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07543120·Phase 2·Recruiting

Apply to this trial

Study of AZD2389 Safety, Tolerability, and Pharmacodynamics in Adults With Steatotic Liver Disease and Advanced Fibrosis

for Liver Fibrosis

19 locations incl. Chandler

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07610837·Phase 2·Recruiting

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Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment

for Smoking

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT07089901·Phase 4·Recruiting

Apply to this trial

BOOST: Blended Onsite and Offsite Structured Exercise Training and Coaching

for Heart Failure With Preserved Ejection Fraction

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 55+

Code: NCT07413198·Recruiting

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Selinexor and Pacritinib in JAK Inhibitor-naïve MF Patients With Cytopenias

for Myelofibrosis

Drug: Pacritinib

3 locations incl. Westwood

Sponsor: John Mascarenhas

Sex: All·Age: 18+

Code: NCT07447817·Phase 2·Not Yet Recruiting

A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease

for Colitis, Ulcerative

15 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07483073·Phase 2·Recruiting

Apply to this trial

A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

for Crohn Disease

Drug: LY4395089

15 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07483099·Phase 2·Recruiting

Apply to this trial

A Study of ASP546C in Adults With Gastroesophageal Cancer, Pancreatic Cancer or Other Solid Tumors

for Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma

9 locations incl. Los Angeles

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07488676·Phase 1, Phase 2·Recruiting

Apply to this trial

Mode of Ventilation During Critical Illness at Multiple Centers

for Respiratory Failure

4 locations incl. Chicago

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07313956·Enrolling By Invitation

Mochida ReFeel for Digital Nerve Injuries

for Digital Nerve Injury

1 location in Charlotte

Sponsor: OrthoCarolina Research Institute, Inc.

Sex: All·Age: 18 - 69

Code: NCT07524465·Phase 4·Not Yet Recruiting

Occlutech AFR Fontan Study

for Failure of Fontan Type Circulation

7 locations incl. Birmingham

Sponsor: Occlutech International AB

Sex: All·Age: All ages

Code: NCT07532369·Not Yet Recruiting

Reducing Post-Operative Opioid Prescribing in Southeastern North Carolina

for Opioid Prescribing

2 locations incl. Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07566182·Not Yet Recruiting

Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD

for Rhinovirus Infection

14 locations incl. Tempe

Sponsor: Altesa Biosciences, Inc.

Sex: All·Age: 40 - 85

Code: NCT07610395·Phase 2·Recruiting

Apply to this trial

Collaboration for Down Syndrome Progress (CDP)

for Down Syndrome

16 locations incl. Orange

Sponsor: RTI International

Sex: All·Age: All ages

Code: NCT07625579·Recruiting

Apply to this trial

Evaluating the Efficacy of Platelet-rich Plasma Therapy in the Treatment of Androgenic Alopecia

for Androgenic Alopecia

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+

Code: NCT03474718·EARLY_Phase 1·Not Yet Recruiting