Mode of Ventilation During Critical Illness at Multiple Centers

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT07313956
Status
Enrolling By Invitation

Conditions

  • Critical Illness
  • Mechanical Ventilation
  • Respiratory Failure

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Volume control — OTHER
    Volume control mode for invasive mechanical ventilation
  • Pressure control — OTHER
    Pressure control mode for invasive mechanical ventilation
  • Adaptive pressure control — OTHER
    Adaptive pressure control for invasive mechanical ventilation

Study Details

The goal of this clinical trial is to learn whether the choice of ventilator mode for patients on breathing machines in the intensive care unit affects their survival and recovery. To do this, researchers will assign the entire participating intensive care unit to one of the three available ventilator modes, alternating which mode is assigned in random sequence every 2 months. The main question it aims to answer is: Does the choice between volume control, pressure control, and adaptive pressure control affect the number of days that patients are alive and free of the breathing machine?

Key Dates

Start date
May 1, 2026
Status verified
May 2026
Primary completion
Jan 31, 2030
Completion
Mar 31, 2030

Study Design

Enrollment
4,785 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Active Comparator: Adaptive Pressure Control Group
    During invasive mechanical ventilation in a study location, adaptive pressure control will be used as the mode for continuous mandatory ventilation.
  • Active Comparator: Pressure Control Group
    During invasive mechanical ventilation in a study location, pressure control will be used as the mode for continuous mandatory ventilation.
  • Active Comparator: Volume Control Group
    During invasive mechanical ventilation in a study location, volume control will be used as the mode for continuous mandatory ventilation.

Primary Outcome Measure

Ventilator-free days in the first 28 days [ Time Frame: From enrollment to 28 days after enrollment ]

Locations (4)

FacilityCityStateZIPSite coordinators
Rush University Medical CenterChicagoIllinois60612-
The Johns Hopkins HospitalBaltimoreMaryland21224-
Wake Forest University Health SciencesWinston-SalemNorth Carolina27109-
Vanderbilt University Medical CenterNashvilleTennessee37232-

Find similar trials in Chicago, IL

By research site
Rush University Medical Center· Chicago, ILThe Johns Hopkins Hospital· Baltimore, MDWake Forest University Health Sciences· Winston-Salem, NCVanderbilt University Medical Center· Nashville, TN

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