A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

Part of paid clinical trials in Chandler, Arizona.

Sponsor
Pfizer
Study ID
NCT07575932
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Body Weight
  • Nutrition Disorders
  • Nutritional and Metabolic Diseases
  • Obesity
  • Overnutrition
  • Overweight
  • Overweight and/or Obesity
  • Overweight or Obesity

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • PF-08653945 — DRUG
    Subcutaneous Injection
  • PF-08653944 — DRUG
    Subcutaneous Injection
  • Placebo — DRUG
    Subcutaneous Injection

Study Details

This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).

Key Dates

Start date
May 11, 2026
Status verified
Jun 2026
Primary completion
Aug 4, 2027
Completion
Jan 5, 2028

Study Design

Enrollment
872 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Cohort 1
    Participants receive subcutaneous injections of PF-08653945 or placebo.
  • Experimental: Cohort 2
    Participants receive subcutaneous injections of PF-08653945 + PF-08653944 or placebo.
  • Experimental: Cohort 3
    Participants receive subcutaneous injections of PF-08653945 + PF-08653944 , PF-08653944 , or placebo.

Primary Outcome Measure

Percent change from baseline in body weight [ Time Frame: Baseline (Week 0) to Week 48 ]

Central Contacts

Locations (48)

FacilityCityStateZIPSite coordinators
Arizona Clinical Trials-ChandlerChandlerArizona85225-
Clinical Research Institute of ArizonaSun City WestArizona85375-
Arizona Clinical Trials (ACT) - TucsonTucsonArizona85711-
Ark Clinical ResearchFountain ValleyCalifornia92708-
Paragon Rx ClinicalGarden GroveCalifornia92840-
Ark Clinical ResearchLong BeachCalifornia90815-
Collaborative Neuroscience Research, LLCLos AlamitosCalifornia90720-
Paradigm Clinical Research-ModestoModestoCalifornia95355-
Paradigm Clinical Research Centers, LLCSan DiegoCalifornia92108-
University Clinical Investigators, IncorporatedTustinCalifornia92780-
Diablo Clinical Research, LLC dba Flourish ResearchWalnut CreekCalifornia94598-
AGA Clinical TrialsHialeahFlorida33012-
Westside Center for Clinical ResearchJacksonvilleFlorida32205-
New Horizon Research CenterMiamiFlorida33165-
Charter ResearchOrlandoFlorida32803-
Atlanta Diabetes AssociatesAtlantaGeorgia30318-
Clinical Research AtlantaStockbridgeGeorgia30281-
Koch Family Medicine Clinical Research/Elite Research NetworkMortonIllinois61550-
Bioluminux Clinical Research IllinoisNapervilleIllinois60540-
Johnson County Clinical TrialsLenexaKansas66219-
DelRicht ResearchMandevilleLouisiana70471-
DelRicht ResearchPrairievilleLouisiana70769-
Patient First Clinical Trials (PFCTRIALS)LuthervilleMaryland21093-
DelRicht ResearchSpringfieldMissouri65807-
Mercury Street Medical Group, PLLCButteMontana59701-
AB Clinical TrialsLas VegasNevada89119-
Alliance Clinical Research Las Vegas (Excel Clinical Research)Las VegasNevada89109-
Bioluminux Clinical ResearchHamiltonNew Jersey08690-
DelRicht ResearchCharlotteNorth Carolina28210-
Monroe Biomedical ResearchMonroeNorth Carolina28112-
Piedmont HealthcareStatesvilleNorth Carolina28625-
Tekton Research, LLC.EdmondOklahoma73013-
Preferred Primary Care PhysiciansPittsburghPennsylvania15236-
Preferred Primary Care PhysiciansUniontownPennsylvania15401-
TMA Headlands LLC (d/b/a Trial Management Associates)Myrtle BeachSouth Carolina29572-
DelRicht ResearchHendersonvilleTennessee37075-
Cedar Health Research - EulessEulessTexas76040-
JCCT-JUNO NW HoustonHoustonTexas77040-
Activian Clinical ResearchKingwoodTexas77339-
3A ResearchPlanoTexas75093-
DelRicht Research @ Zomnir Family MedicineProsperTexas75078-
Tekton Research, LLC.San AntonioTexas78258-
Worldwide Clinical TrialsSan AntonioTexas78217-
DM Clinical ResearchTomballTexas77375-
Alpine Medical GroupSalt Lake CityUtah84107-
Wasatch Clinical Research, LLCSalt Lake CityUtah84107-
Manassas Clinical Research CenterManassasVirginia20110-
DelRicht ResearchViennaVirginia22182-

Find similar trials in Chandler, AZ

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Arizona Clinical Trials-Chandler· Chandler, AZClinical Research Institute of Arizona· Sun City West, AZArizona Clinical Trials (ACT) - Tucson· Tucson, AZArk Clinical Research· Fountain Valley, CAParagon Rx Clinical· Garden Grove, CAArk Clinical Research· Long Beach, CA

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