A Phase 2 Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients With Severe Asthma

Part of paid clinical trials in Lancaster, California.

Sponsor
Kinaset Therapeutics Inc
Study ID
NCT07532265
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Frevecitinib — DRUG
    Frevecitinib (KN-002) delivered via a dry powder inhaler (DPI)
  • Placebo — DRUG
    Matching placebo to frevecitinib

Study Details

A Phase 2 Dose Ranging Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) Over a 12-Week Treatment Period in Patients With Severe Asthma Not Controlled With Medium to High Dose ICS/LABA

Key Dates

Start date
Jun 1, 2026
Status verified
Apr 2026
Primary completion
Nov 30, 2027
Completion
Nov 30, 2027

Study Design

Enrollment
512 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Frevecitinib Dose 1
    Drug: Frevecitinib
  • Experimental: Frevecitinib Dose 2
    Drug: Frevecitinib
  • Experimental: Frevecitinib Dose 3
    Drug: Frevecitinib
  • Placebo Comparator: Frevecitinib (KN-002) matching placebo
    Placebo

Primary Outcome Measure

Pre-BD FEV1 [ Time Frame: Week 12 ]

Locations (15)

FacilityCityStateZIPSite coordinators
Research siteLancasterCalifornia93534-
Research siteSan JoseCalifornia95117-
Research siteBrandonFlorida33511-
Research siteMiamiFlorida33137-
Research siteTampaFlorida33607-
Research siteChicagoIllinois60612-
Research siteKansas CityMissouri66160-
Research siteSt LouisMissouri63141-
Research siteCharlotteNorth Carolina28277-
Research sitePittsburghPennsylvania15213-
Research siteRock HillSouth Carolina29732-
Research siteDallasTexas75225-
Research siteHoustonTexas77099-
Research siteSan AntonioTexas78258-
Research siteWilliamsburgVirginia23188-

Find similar trials in Lancaster, CA

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
Research site· Lancaster, CAResearch site· San Jose, CAResearch site· Brandon, FLResearch site· Miami, FLResearch site· Tampa, FLResearch site· Chicago, IL

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