Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Bastiaan Driehuys
Study ID
NCT07139899
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Hyperpolarized Xenon 129 — COMBINATION_PRODUCT
    Pulmonary magnetic resonance imaging using hyperpolarized xenon-129 gas as an inhaled contrast agent

Study Details

In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.

Key Dates

Start date
Nov 17, 2025
Status verified
Nov 2025
Primary completion
Nov 30, 2026
Completion
Sep 30, 2027

Study Design

Enrollment
5 participants (estimated)

Primary Outcome Measure

Ventilation Defect in Mucus-blocked regions [ Time Frame: 12 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Duke University Medical CenterDurhamNorth Carolina27713-

Find similar trials in Durham, NC

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
Duke University Medical Center· Durham, NC

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