Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Severe Asthma

Part of paid clinical trials in Kansas City, Kansas.

Sponsor
University of Kansas Medical Center
Study ID
NCT06985225
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Hyperpolarized 129 Xenon — COMBINATION_PRODUCT
    Xenon gas contrast agent for MRI

Study Details

In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.

Key Dates

Start date
Jun 1, 2025
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
5 participants (estimated)

Arms

  • Arm: Main Group
    Patients with Severe Asthma with a high T2 phenotype

Primary Outcome Measure

Ventilation Defect in Mucus blocked Regions [ Time Frame: 12-weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Kansas Medical CenterKansas CityKansas66160
Cristal Monge
[email protected]
913-945-9399
Peter Niedbalski, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Kansas City, KS

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
University of Kansas Medical Center· Kansas City, KS

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