SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT07429292
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Healthy Volunteers
  • Sympathetic Activity

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Lidocaine 2% — DRUG
    Small-volume injection (5 mL) of 2% lidocaine around radial artery under ultrasound guidance.

Study Details

The SPARK Study evaluates changes in peripheral sympathetic vasomotor activity following a targeted, ultrasound-guided periarterial sympathetic block of the distal radial artery in healthy volunteers. Autonomic reactivity will be assessed before and after the block using digit-specific pulse-amplitude index and infrared thermography during standardized cold pressor testing.

Key Dates

Start date
May 31, 2026
Status verified
Mar 2026
Primary completion
Dec 31, 2026
Completion
Apr 30, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Left Wrist Block
    Ultrasound-guided periarterial block with 2% lidocaine at left wrist.
  • Experimental: Right Wrist Block
    Ultrasound-guided periarterial block with 2% lidocaine at right wrist.

Primary Outcome Measure

Pulse amplitude index (PAI) [ Time Frame: PAI will be measured at: 1) Baseline; 2) after the first cold pressor test at 0, 5, 10, and 15 minutes; 3) after the sympathetic block at 5 and 10 minutes; 4) after the second cold pressor test at 0, 5, 10, and 15 minutes. ]

Locations (1)

FacilityCityStateZIPSite coordinators
Duke University Medical CenterDurhamNorth Carolina27710-

Find similar trials in Durham, NC

By research site
Duke University Medical Center· Durham, NC

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