Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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Feasibility of Symptom Management for Patients With Metastatic Breast Cancer to Increase Exercise

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07313306·Recruiting

Apply to this trial

A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract

for Carcinoma, Transitional Cell

60 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07218380·Phase 3·Recruiting

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A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH

for Non-alcoholic Fatty Liver Disease

43 locations incl. Arcadia

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 75

Code: NCT07221188·Phase 3·Recruiting

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Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma

for Advanced Or Metastatic Merkel Cell Carcinoma

18 locations incl. Los Angeles

Sponsor: TuHURA Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT06947928·Phase 2, Phase 3·Recruiting

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A Study of S-337395 in Symptomatic Nonhospitalized Adults With Respiratory Syncytial Virus (RSV) Who Are at High Risk of Progression to Severe Disease

for Respiratory Syncytial Virus Infections

33 locations incl. Los Angeles

Sponsor: Shionogi

Sex: All·Age: 18+

Code: NCT07214571·Phase 2·Recruiting

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A Study to Evaluate the Effect of Obicetrapib/Ezetimibe 10 mg Fixed-Dose Combination or Obicetrapib 10 mg Daily on Top of Guideline-Recommended Lipid-Lowering Therapy in Participants With Type 2 Diabetes and/or Metabolic Syndrome

for Lipidemia

Drug: Obicetrapib

20 locations incl. Sun City West

Sponsor: NewAmsterdam Pharma

Sex: All·Age: 18+

Code: NCT07219602·Phase 3·Recruiting

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Getting to Zero Among HHI MSM in the American South

for HIV Infections

1 location in Durham

Sponsor: HIV Prevention Trials Network

Sex: Male·Age: 15+·Accepts healthy volunteers

Code: NCT05075967·Enrolling By Invitation

Study of Choline Chloride for Injection in Adolescent and Adult Patients With Intestinal Failure Receiving Long Term Parenteral Support

for Choline Deficiency

7 locations incl. Aurora

Sponsor: Protara Therapeutics

Sex: All·Age: 12+

Code: NCT06910943·Phase 2, Phase 3·Recruiting

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Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

for Miscellaneous Neoplasm, Nos

231 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07091617·Recruiting

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A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL

for Diabetic Foot Ulcer (DFU)

10 locations incl. DeLand

Sponsor: HealthTech Wound Care

Sex: All·Age: 18 - 80

Code: NCT07172893·Phase 4·Recruiting

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Low Intensity Focused Ultrasound Stimulation in Stroke Patients - Parameter Optimization

for Stroke

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT07220005·Recruiting

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A Study to Learn About a Clostridioides Difficile Vaccine in People 65 Years of Age and Older

for Clostridioides Difficile Associated Disease

135 locations incl. Athens

Sponsor: Pfizer

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07282665·Phase 3·Recruiting

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Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody

for Clostridioides Difficile Infection

42 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07285213·Phase 2·Recruiting

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Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors

for Fatigue

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06819254·Phase 4·Recruiting

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Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression

for Ovarian Cancer

Drug: INCB123667

29 locations incl. Anchorage

Sponsor: Incyte Corporation

Sex: Female·Age: 18+

Code: NCT07214779·Phase 3·Recruiting

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Kaempferol Absorption and Pharmacokinetics Evaluation

for No Disease

3 locations incl. New York

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07322406·Recruiting

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Comparative Study of Ziplyft Treatment vs. Traditional Blepharoplasty for Upper Eyelid Rejuvenation

for Dermatochalasis of Upper Eyelid

1 location in Oxford

Sponsor: Osheru Inc.

Sex: All·Age: 35+

Code: NCT07250139·Recruiting

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Liquid Biopsy in Glioblastoma Treated With Chemoradiation and an Oxygen Therapeutic

for Glioblastoma (GBM)

4 locations incl. Tucson

Sponsor: NuvOx LLC

Sex: All·Age: 18+

Code: NCT07417774·Enrolling By Invitation

A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.

for Chronic Kidney Disease and Hypertension

Drug: Dapagliflozin

18 locations incl. Surprise

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07222917·Phase 2·Recruiting

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Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)

for Chronic Neuropathic Pain

11 locations incl. Scottsdale

Sponsor: Sangamo Therapeutics

Sex: All·Age: 18+

Code: NCT06980948·Phase 1, Phase 2·Recruiting

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A Study Assessing Safety, Tolerability, and Efficacy of INNA-051 in Preventing Respiratory Illness Due to Viral Infections in Healthy Adults 18 to 45 Years of Age

for Viral Respiratory Infection

5 locations incl. Baltimore

Sponsor: ENA Respiratory Pty Ltd

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07222670·Phase 2·Recruiting

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A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis

for Plaque Psoriasis

Drug: Deucravacitinib

42 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 12 - 17

Code: NCT06979453·Phase 3·Recruiting

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A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

for Gastrointestinal Neoplasms

35 locations incl. Phoenix

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT07218926·Phase 3·Recruiting

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A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

for Squamous Cell Carcinoma of Head and Neck

Drug: Amivantamab

41 locations incl. Chandler

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07276399·Phase 3·Recruiting

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A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-1)

for Severe Asthma

34 locations incl. Northridge

Sponsor: Generate Biomedicines

Sex: All·Age: 12 - 80

Code: NCT07276724·Phase 3·Recruiting

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Dose Ranging Study of ORKA-001 in Patients With Moderate-to-Severe Plaque Psoriasis

for Plaque Psoriasis

20 locations incl. Phoenix

Sponsor: Oruka Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07290569·Phase 2·Recruiting

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A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitean-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer

for Locally Advanced Urothelial Carcinoma

148 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06524544·Phase 3·Recruiting

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A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

for Alzheimer Disease

Drug: KarXT

48 locations incl. Chandler

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 55 - 90

Code: NCT06937229·Phase 3·Recruiting

Apply to this trial

Sex Differences in Barriers and Participation in Physical Activity During and Following Cardiac Rehabilitation

for Cardiac Rehabilitation

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07214350·Recruiting

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A Phase 1 Study of JMT108 in Participants With Advanced Solid Tumors

for Cancer

3 locations incl. Huntersville

Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07317505·Phase 1·Recruiting

Apply to this trial

Dialysis Geriatric Care Model

for Chronic Kidney Diseases

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 55+

Code: NCT05793138·Enrolling By Invitation

A Phase 2 Study of CRD-4730 in CPVT

for Catecholaminergic Polymorphic Ventricular Tachycardia

4 locations incl. San Francisco

Sponsor: Cardurion Pharmaceuticals, Inc.

Sex: All·Age: 18 - 99

Code: NCT06658899·Phase 2·Recruiting

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Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

for Castration-Sensitive Prostate Carcinoma

Drug: Apalutamide

194 locations incl. Tucson

Sponsor: Alliance for Clinical Trials in Oncology

Sex: Male·Age: 18+

Code: NCT06931340·Phase 3·Recruiting

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Modulation of Brain Rhythms in Stroke

for Stroke

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 45 - 80

Code: NCT07121582·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan

for Solid Tumors Harboring MET Amplification

16 locations incl. Beverly Hills

Sponsor: AbbVie

Sex: All·Age: 12+

Code: NCT07196644·Phase 2·Recruiting

Apply to this trial

mHealth for Early Psychosis Caregivers in Statewide Program Outreach

for Caregiver

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07225179·Recruiting

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Virtual Reality Use for ICU Mobility

for Intensive Care Unit ICU

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07234201·Recruiting

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First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for Esophageal Squamous Cell Carcinoma

10 locations incl. Scottsdale

Sponsor: Plexium, Inc.

Sex: All·Age: 18+

Code: NCT07284186·Phase 1·Recruiting

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An Efficacy and Safety Study of DFL24498 in the Treatment of AKC

for Atopic Keratoconjunctivitis

8 locations incl. Jacksonville

Sponsor: Dompé Farmaceutici S.p.A

Sex: All·Age: 18 - 65

Code: NCT07395232·Phase 3·Recruiting

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Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

for Type 2 Diabetes

52 locations incl. Chandler

Sponsor: Sparrow Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07296484·Phase 2·Recruiting

Apply to this trial