Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

Conditions

• Miscellaneous Neoplasm, Nos
• Non-Neoplastic Condition, Nos

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Telemedicine — OTHER
  Undergo telehealth visit with genetic counselor for pretest genetic education
• Genetic Testing — OTHER
  Complete standard of care genetic testing
• Telemedicine — OTHER
  Undergo telehealth visit with genetic counselor for disclosure of results
• Internet-Based Intervention — OTHER
  Receive access to Genetic Journey Chatbot
• Educational Intervention — OTHER
  Complete digital pre-test genetic education
• Patient Navigation — BEHAVIORAL
  Utilize chatbot to answer questions, assess barriers, and provide reminders for next steps during the testing period
• Interview — OTHER
  Complete interview
• Survey Administration — OTHER
  Ancillary studies

Study Details

This phase III trial compares the use of a digital chatbot enabled intervention to standard remote genetic services for increasing uptake of genetic counseling and testing among adolescents and young adult (AYA) cancer patients. Genetic testing for cancer predisposition syndromes has become standard evidence-based practice and can inform enhanced screening and risk reducing measures to reduce cancer morbidity and mortality. Despite this, many AYAs are not receiving recommended genetic counseling and testing. Offering remote telehealth services can address access barriers and chatbots and texting interventions could enhance patient outcomes and reduce provider and staff time. The use of a digital chatbot enabled intervention may be equally as effective as standard remote genetic services in AYA cancer patients undergoing genetic testing.

Key Dates

Start date

Dec 10, 2025

Status verified

Jun 2026

Primary completion

Apr 28, 2028

Completion

Apr 30, 2029

Study Design

Enrollment

535 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

HEALTH_SERVICES_RESEARCH

Arms

• Active Comparator: Arm I (standard remote genetic services)
  Patients attend a standard of care telehealth visit with a genetic counselor for pretest genetic education. Patients then undergo standard of care genetic testing and attend a telehealth visit with a genetic counselor for disclosure of results.
• Experimental: Arm II (Genetic Journey Chatbot)
  Patients receive access to the Genetic Journey Chatbot and choose to complete digital pre-test genetic education via the digital tool or via telehealth visit with a genetic counselor. Via the chatbot, patients may request a telehealth visit with a genetic counselor at any time to answer unresolved questions. Patients then undergo standard of care genetic testing and attend a telehealth visit with a genetic counselor for disclosure of results. The chatbot remains available to answer questions, assess barriers, and provide reminders for next steps during the testing period.

Primary Outcome Measure

Uptake of genetic counseling [ Time Frame: Within 6 months of baseline ]

Central Contacts

• Rachel Wills
  773-702-9171
  [email protected]

Locations (231)

Find similar trials in Anchorage, AK

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