Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors

Part of paid clinical trials in Winston-Salem, North Carolina.

Sponsor
Wake Forest University Health Sciences
Study ID
NCT06819254
Phase
PHASE4
Status
Recruiting
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Conditions

  • Fatigue

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Fisetin followed by Placebo — DRUG
    Fisetin 20 mg/kg per dose twice daily on two consecutive days for two consecutive weeks. Participants will return on day 14 for a blood draw followed by a 14-day wash-out. At the 4-week visit participants will receive a cross-over placebo-controlled dosing regimen to be taken twice daily on two consecutive days for two consecutive weeks.
  • Placebo followed by Fisetin — DRUG
    Placebo twice daily on two consecutive days for two consecutive weeks. Participants will return on day 14 for a blood draw followed by a 14-day wash-out. At the 4-week visit participants will receive a cross-over Fisetin 20 mg/kg per dose twice daily on two consecutive days for two consecutive weeks.

Study Details

The purpose of this study is to find out if taking a Fisetin supplement can decrease fatigue among older cancer survivors.

Key Dates

Start date
Dec 9, 2025
Status verified
Dec 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER

Arms

  • Experimental: Fisetin - Placebo
    Two-week regimen of Fisetin supplement followed by two-week regimen of placebo.
  • Experimental: Placebo - Fisetin
    Two-week regimen of placebo followed by two-week regimen of Fisetin supplement.

Primary Outcome Measure

Change in Pittsburgh Fatigability Scale (PFS) [ Time Frame: Baseline to Week 2 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Atrium Health Wake Forest Baptist HospitalWinston-SalemNorth Carolina27157
Kim Kennedy, MS
[email protected]
336-713-8567
Stephen Kritchevsky, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Winston-Salem, NC

By research site
Atrium Health Wake Forest Baptist Hospital· Winston-Salem, NC

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