Behavioral and Neural Representations of Subjective Effort Cost

Part of paid clinical trials in Baltimore, Maryland.

Sponsor
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Study ID
NCT04041154
Status
Recruiting
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Conditions

  • Fatigue

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Cognitive Fatigue — BEHAVIORAL
    Participants will perform a cognitively demanding task (spatial attention task), repeatedly, to induce cognitive fatigue.
  • Physical Fatigue — BEHAVIORAL
    Participants will perform a physically demanding task (grip force exertion task), repeatedly, to induce cognitive fatigue.
  • Rewarding Stimuli — BEHAVIORAL
    Reward-associated stimuli will be used to study how reward-induced changes in motivational state influence effort choices.

Study Details

The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circuits to represent cognitive and physical effort value, and that fatigue and enhanced motivation will influence the subjective value of effort.

Key Dates

Start date
Aug 1, 2018
Status verified
Jan 2026
Primary completion
Dec 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
185 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Cognitive Fatigue
    We will use a behavioral intervention. Participants will perform a cognitively demanding task, repeatedly, to induce cognitive fatigue.
  • Experimental: Physical Fatigue
    We will use a behavioral intervention. Participants will perform a physically demanding task (grip force exertion task), repeatedly, to induce cognitive fatigue.
  • Experimental: Rewarding Stimuli
    We will use a behavioral intervention. Reward-associated stimuli will be used to study how reward-induced changes in motivational state influence effort choices.

Primary Outcome Measure

Mean of cognitive subjective effort parameters (from behavioral choice data) [ Time Frame: 1 day ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Kennedy Krieger InstituteBaltimoreMaryland21209
Anthony Gonzalez
[email protected]
443-923-2716

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Kennedy Krieger Institute· Baltimore, MD

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