A Phase 2 Study of CRD-4730 in CPVT

Part of paid clinical trials in San Francisco, California.

Sponsor
Cardurion Pharmaceuticals, Inc.
Study ID
NCT06658899
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Catecholaminergic Polymorphic Ventricular Tachycardia

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

  • CRD-4730 — DRUG
    Oral CRD-4730 in tablet form
  • Placebo — DRUG
    Placebo to match CRD-4730 in tablet form

Study Details

This is a Phase 2, multicenter, double-blind, sponsor blinded, placebo-controlled, repeat-dose clinical study of CRD-4730 to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of CRD-4730 to participants with Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT). Participants with CPVT will complete a 3-period, randomized 3-sequence study. Each participant will be randomized to one of the 3 sequences in which they will receive 2 different doses of CRD-4730 and 1 dose of matching placebo.

Key Dates

Start date
Dec 1, 2025
Status verified
Nov 2025
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
12 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Dose 1
    CRD-4730 Dose 1 Tablet
  • Experimental: Dose 2
    CRD 4730 Dose 2 Tablet
  • Placebo Comparator: Dose 3
    Placebo tablet to match CRD-4730

Primary Outcome Measure

Primary Outcome Measures [ Time Frame: Baseline to Day 101 ]

Central Contacts

Locations (4)

FacilityCityStateZIPSite coordinators
Cardurion Investigative SiteSan FranciscoCalifornia94143-
Cardurion Investigative SiteMorrisvilleNorth Carolina27560-
Cardurion Investigative SiteHoustonTexas77030-
Cardurion Investigative SiteMadisonWisconsin53792-

Find similar trials in San Francisco, CA

By research site
Cardurion Investigative Site· San Francisco, CACardurion Investigative Site· Morrisville, NCCardurion Investigative Site· Houston, TXCardurion Investigative Site· Madison, WI

Related Studies