Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Sangamo Therapeutics
Study ID
NCT06980948
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Chronic Neuropathic Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ST-503 — GENETIC
    Genomic Medicine
  • Sham (No Treatment) — PROCEDURE
    Sham Procedure

Study Details

This research is being done to study a possible treatment for refractory pain due to small fiber neuropathy (SFN). ST-503 is intended to deliver a modified copy of the gene which will ideally repress Nav1.7 tissue-related pain signals reaching the brain, which should reduce the refractory pain due to small fiber neuropathy (SFN).

Key Dates

Start date
Dec 4, 2025
Status verified
Apr 2026
Primary completion
Jul 31, 2027
Completion
Jul 31, 2028

Study Design

Enrollment
27 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Sham Comparator: Sham Controlled Study
  • Experimental: Investigational Agent

Primary Outcome Measure

Incidence and severity of treatment emergent adverse events (TEAEs) [ Time Frame: 12 weeks ]

Central Contacts

Locations (11)

FacilityCityStateZIPSite coordinators
HonorHealthScottsdaleArizona85260
Study Coordinator
[email protected]
University of Arkansas for Medical SciencesLittle RockArkansas72205
Study Coordinator
[email protected]
The University of California, San DiegoLa JollaCalifornia92093-
Johns Hopkins UniversityBaltimoreMaryland21218
Study Coordinator
[email protected]
Massachusetts General HospitalBostonMassachusetts02114
Study Coordinator
[email protected]
Dartmouth Hitchcock Medical CenterLebanonNew Hampshire03766-
Columbia University Irving Medical Center (CUIMC) and New York-Presbyterian Hospital (NYPH)New YorkNew York10027
Study Coordinator
[email protected]
University of North Carolina Medical CenterChapel HillNorth Carolina27514-
Vanderbilt UniversityNashvilleTennessee37235-
University of UtahSalt Lake CityUtah84112-
Virginia Commonwealth UniversityRichmondVirginia23284
Study Coordinator
[email protected]

Find similar trials in Scottsdale, AZ

By research site
HonorHealth· Scottsdale, AZUniversity of Arkansas for Medical Sciences· Little Rock, ARThe University of California, San Diego· La Jolla, CAJohns Hopkins University· Baltimore, MDMassachusetts General Hospital· Boston, MADartmouth Hitchcock Medical Center· Lebanon, NH

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