Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab

for Newly Diagnosed Glioblastoma

Drug: Relatlimab

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06816927·Phase 2·Recruiting

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A Study to Evaluate LY3537021 for the Treatment of Nausea and Vomiting Caused by Chemotherapy in Adults With Cancer

for Nausea

19 locations incl. Greenbrae

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07169851·Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of Cannabidiol Oral Solution (CBD-OS [GWP42003-P, JZP926]) for the Treatment of Focal-Onset Seizures

for Focal Seizures

24 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 12 - 75

Code: NCT07233239·Phase 1·Recruiting

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Observational Study of VYKAT™ XR in Patients With Prader-Willi Syndrome

for Prader-Willi Syndrome

15 locations incl. Los Angeles

Sponsor: Soleno Therapeutics, Inc.

Sex: All·Age: 4+

Code: NCT07450664·Enrolling By Invitation

Medically Tailored Meals for Kids

for Pediatric Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 12 - 99

Code: NCT06814795·Recruiting

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A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy

for Advanced Solid Tumors

Drug: Rilvegostomig

3 locations incl. Huntersville

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07161414·Phase 1·Recruiting

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SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

for Type 1 Diabetes

23 locations incl. San Francisco

Sponsor: SAb Biotherapeutics, Inc.

Sex: All·Age: 5 - 40

Code: NCT07187531·Phase 2·Recruiting

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Detrusor Nerve Radiofrequency Ablation for Overactive Bladder in Women

for Overactive Bladder

9 locations incl. Palo Alto

Sponsor: InMode MD Ltd.

Sex: Female·Age: 22 - 80

Code: NCT07209397·Recruiting

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A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions.

for Ankle Arthrodesis or Arthroplasty

5 locations incl. Vail

Sponsor: Kuros Biosurgery AG

Sex: All·Age: 18 - 75

Code: NCT07225751·Recruiting

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Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy

for Obstructive Sleep Apnea

13 locations incl. Northridge

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07226765·Phase 3·Recruiting

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Mirena for the Treatment of Nonatypical Endometrial Hyperplasia for 6 Months

for Endometrial Hyperplasia

69 locations incl. Birmingham

Sponsor: Bayer

Sex: Female·Age: 18+

Code: NCT06904274·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

for Parkinson's Disease

Drug: Prasinezumab

42 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 85

Code: NCT07174310·Phase 3·Recruiting

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REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants

for Symptomatic Venous Thromboembolism (VTE)

19 locations incl. Rancho Mirage

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07213778·Phase 3·Recruiting

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Mobilization and Outcomes After Venous Closure

for Venous Vascular Closure

3 locations incl. Littleton

Sponsor: Cordis US Corp.

Sex: All·Age: All ages

Code: NCT07246902·Recruiting

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Self-collection for HPV Testing to Improve Cervical Cancer Prevention (SHIP) Trial (LMI-001-A-S04)

for Cervical Carcinoma

18 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 25+·Accepts healthy volunteers

Code: NCT07281430·Recruiting

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Assessment of AI Program 'DRISTi' as a Screening Tool

for Diabetic Retinopathy (DR)

2 locations incl. Oxford

Sponsor: Artelus AI

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT07222293·Recruiting

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A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.

for Epithelial Ovarian Cancer

64 locations incl. Birmingham

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06890338·Phase 2·Recruiting

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A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

for Metastatic Castration-resistant Prostate Cancer

13 locations incl. San Francisco

Sponsor: K36 Therapeutics, Inc.

Sex: Male·Age: 18+

Code: NCT07103018·Phase 1·Recruiting

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Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy

for Diabetic Peripheral Neuropathic Pain

75 locations incl. Birmingham

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 80

Code: NCT07231419·Phase 3·Recruiting

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Zymfentra (Infliximab-dyyb) REal World Cohort STudy

for Ulcerative Colitis (UC)

9 locations incl. New Haven

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+

Code: NCT07237516·Recruiting

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A Study to Assess the Adverse Events, Change in Disease Activity, and How Oral ABBV-711 Tablets Move Through the Body as a Monotherapy and in Combination With Intravenously Infused Budigalimab (ABBV-181), in Adults With Advanced Squamous Tumors

for Advanced Squamous Tumors

6 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07241039·Phase 1·Recruiting

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Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma

for Severe Asthma

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18 - 65

Code: NCT07139899·Recruiting

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A Phase 1/1b of RNDO-564 Single Agent or in Combination With Pembrolizumab in Bladder Cancer and Other Solid Tumors Associated With Nectin-4

for Non Small Cell Lung Cancer

11 locations incl. San Francisco

Sponsor: Rondo Therapeutics

Sex: All·Age: 18+

Code: NCT07218003·Phase 1·Enrolling By Invitation

This Study is a Non-interventional Disease Registry of Adolescent and Adult Patients With Atopic Dermatitis Who Initiate or Switch Any Systemic Treatment

for Atopic Dermatitis

43 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 12+

Code: NCT07290803·Recruiting

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Photon-counting CT in Chest Imaging

for COPD (Chronic Obstructive Pulmonary Disease)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT07031336·Recruiting

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R.E.C.K vs Exparel in Robotic Nephrectomy

for Renal Carcinoma

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07092566·Phase 3·Recruiting

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ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

for Major Depressive Disorder (MDD)

21 locations incl. Birmingham

Sponsor: ACADIA Pharmaceuticals Inc.

Sex: All·Age: 18 - 65

Code: NCT07284667·Phase 2·Recruiting

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A Study to Find Out Whether BI 765423 Has an Effect on Lung Function in People With Idiopathic Pulmonary Fibrosis (IPF) With or Without Standard Treatment

for Idiopathic Pulmonary Fibrosis

Drug: BI 765423

15 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 40+

Code: NCT07036523·Phase 2·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer

for Ovarian Cancer

23 locations incl. La Jolla

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT07059845·Phase 2·Recruiting

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A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease

for Systemic Lupus Erythematosus (With and Without Nephritis)

12 locations incl. Phoenix

Sponsor: Allogene Therapeutics

Sex: All·Age: 18 - 69

Code: NCT07085104·Phase 1·Recruiting

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Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers

for Cardiovascular Disease Acute

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07159269·Recruiting

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A Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Sonelokimab in Participants With Psoriatic Arthritis

for Arthritis, Psoriatic

16 locations incl. Avondale

Sponsor: MoonLake Immunotherapeutics AG

Sex: All·Age: 18+

Code: NCT07223138·Phase 3·Enrolling By Invitation

A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.

for Hidradenitis Suppurativa

Drug: Ritlecitinib

32 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18 - 75

Code: NCT07228390·Phase 2·Recruiting

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HMCT/CT2401: Abatacept GVHD Prophylaxis Following Omidubicel HCT

for Hematologic Malignancy

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06731504·EARLY_Phase 1·Recruiting

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Virtual Village for Young Parents

for Gender-based Violence

1 location in Durham

Sponsor: RTI International

Sex: All·Age: 16 - 21·Accepts healthy volunteers

Code: NCT07226401·Recruiting

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Impact of Anatomy-Based Cochlear Implant Programming on Early Performance

for Hearing Loss, Unilateral

6 locations incl. Iowa City

Sponsor: Med-El Corporation

Sex: All·Age: 18+

Code: NCT06734039·Enrolling By Invitation

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

for Pulmonary Hypertension

13 locations incl. Sacramento

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07073820·Phase 2·Recruiting

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A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis

for Eosinophilic Esophagitis (EoE)

Drug: Dupilumab

10 locations incl. Phoenix

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 6 Months - 6

Code: NCT07112378·Phase 3·Recruiting

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A Long-Term Study of Bivamelagon in Participants With Hypothalamic Obesity (HO)

for Hypothalamic Obesity

6 locations incl. Aurora

Sponsor: Rhythm Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07156578·Phase 2·Enrolling By Invitation

Pediatrics Mobile CT

for Pediatric Abdominal Imaging

1 location in Durham

Sponsor: Duke University

Sex: All·Age: Up to 5

Code: NCT07166926·Recruiting

Apply to this trial