Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas

for BRAF V600 Mutation

Drug: Dabrafenib

6 locations incl. Birmingham

Sponsor: University of California, San Francisco

Sex: All·Age: 12 Months - 25

Code: NCT07110246·Phase 2·Recruiting

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A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation

for Atrial Fibrillation (AF)

32 locations incl. Birmingham

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT07187115·Recruiting

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Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

for Osteoarthritis Knee Pain

20 locations incl. San Diego

Sponsor: Saol Therapeutics Inc

Sex: All·Age: 40+

Code: NCT07226258·Phase 3·Recruiting

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Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

for Extensive Stage Lung Small Cell Carcinoma

148 locations incl. Loma Linda

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06769126·Phase 2·Recruiting

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Comparison of Urinary Flow Study

for Urinary Retention

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+

Code: NCT06918067·Recruiting

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A Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa Colonization

for Bronchiectasis With Pseudomonas Aeruginosa Colonization

25 locations incl. Orange

Sponsor: AstraZeneca

Sex: All·Age: 12+

Code: NCT07088926·Phase 2·Recruiting

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A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

for Non-muscle Invasive Bladder Cancer

39 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07206225·Phase 1·Recruiting

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A Study to Assess the Concentration of Bimekizumab in Mature Breast Milk From Mothers Receiving Treatment With Bimzelx® (Bimekizumab)

for Moderate to Severe Plaque Psoriasis

Drug: Bimekizumab

4 locations incl. Santa Monica

Sponsor: UCB Biopharma SRL

Sex: Female·Age: 18+

Code: NCT06888193·Phase 1·Recruiting

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Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain

for Pain, Acute

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07053774·Phase 2·Recruiting

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Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

for Locally Advanced Cervical Adenocarcinoma

260 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07061977·Phase 3·Recruiting

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Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain

for Tobacco Use

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 21 - 65

Code: NCT06983678·Recruiting

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Timing of Physician Rounds for Antepartum Patients

for Physician Rounds

2 locations incl. Durham

Sponsor: Duke University

Sex: Female·Age: 18+

Code: NCT07215507·Recruiting

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A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart

21 locations incl. Little Rock

Sponsor: Vasa Therapeutics

Sex: All·Age: 50+

Code: NCT07219511·Phase 1·Recruiting

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Translation of Acoustic Angiography: Contrast Enhanced Super Resolution (CESR) Imaging

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07225114·Phase 2·Recruiting

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Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer 2

for Bladder Cancer

6 locations incl. Tampa

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT07225127·Recruiting

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Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED).

for Dry Eye Disease

10 locations incl. Glendale

Sponsor: Instituto Grifols, S.A.

Sex: All·Age: 18+

Code: NCT07264517·Phase 2·Recruiting

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Immersive Physical Therapy in the Neonatal Intensive Care Unit (NICU)

for Physical Therapy

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 0 - 99

Code: NCT06927037·Recruiting

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COMPARE - Pediatric Inflammatory Bowel Disease (PIBD)

for Ulcerative Colitis, Pediatric

4 locations incl. Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 - 18

Code: NCT07198113·Recruiting

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Human Menopausal Gonadotropin Research in Infertility Assessing Cumulative Live Birth With Frozen Embryo Transfer.

for Infertility (IVF Patients)

16 locations incl. Encino

Sponsor: Granata Bio Corporation

Sex: Female·Age: 18 - 42

Code: NCT07216742·Phase 3·Recruiting

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Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos

for Complex Aneuploidy

11 locations incl. Margate

Sponsor: Shady Grove Fertility Reproductive Science Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07227116·Recruiting

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I-DECIDE After Bronchiolitis Hospitalization

for Bronchiolitis Acute

56 locations incl. Birmingham

Sponsor: Seattle Children's Hospital

Sex: All·Age: 0 Months - 24 Months

Code: NCT07243652·Recruiting

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A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

for Uncontrolled Hypertension

20 locations incl. San Jose

Sponsor: Retension Pharmaceuticals. Inc.

Sex: All·Age: 18 - 70

Code: NCT07142356·Phase 2·Recruiting

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An Eight-Week Study to Evaluate the Safety and Efficacy of VSJ-110 Compared to Placebo in the Treatment of Dry Eye

for Dry Eye

5 locations incl. Newport Beach

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07179055·Phase 2·Recruiting

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A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks

for Eosinophilic Esophagitis

41 locations incl. Little Rock

Sponsor: Phathom Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06851559·Phase 2·Recruiting

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Study of S-606001 as an Add-on to Enzyme Replacement Therapy (ERT) in Participants With Late-onset Pompe Disease (LOPD)

for Pompe Disease

9 locations incl. Irvine

Sponsor: Shionogi

Sex: All·Age: 18+

Code: NCT07123155·Phase 2·Recruiting

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Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD

for Chronic Graft Versus Host Disease

Drug: Fostamatinib

1 location in Durham

Sponsor: Stefanie Sarantopoulos, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT06233110·Phase 1·Recruiting

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Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMD

for Geographic Atrophy (GA)

27 locations incl. Gilbert

Sponsor: ONL Therapeutics

Sex: All·Age: 55+

Code: NCT06659445·Phase 2·Recruiting

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort C: Bevacizumab

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Bevacizumab

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701656·Phase 2·Recruiting

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Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

for Chronic Kidney Disease(CKD)

6 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06906627·Recruiting

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Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)

for Chronic Kidney Disease(CKD)

6 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06906640·Recruiting

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Characterizing the Microvascular Environment of Bladder Cancer With Super-Resolution Ultrasound Localization Microscopy

for Bladder Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06986304·Recruiting

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A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation

for Atrial Fibrillation

5 locations incl. Tupelo

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07217067·Phase 2·Recruiting

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Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery

for Unilateral Vocal Cord Paralysis

10 locations incl. La Jolla

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07579364·Enrolling By Invitation

129 Xenon Imaging in Patients Treated With Sotatercept

for Pulmonary Hypertension

1 location in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18 - 75

Code: NCT06351345·Phase 2·Recruiting

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Using Tailored mHealth Strategies to Promote Weight Management Among Adolescent and Young Adult Cancer Survivors

for Obesity

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18 - 39

Code: NCT06848491·Recruiting

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RaDIANT Health Systems Intervention

for End Stage Renal Disease (ESRD)

5 locations incl. Atlanta

Sponsor: Indiana University

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07033117·Recruiting

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Observational Study to Describe Health-Related Quality of Life and Measure Disease Burden Among Patients With Long QT Syndrome Types (LQTS) 2 and 3

for Long QT Syndrome Type 3

1 location in Greenville

Sponsor: Thryv Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07075445·Recruiting

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Optimizing the AYA Survivors' Coping and Emotional Needs Toolkit

for Depression

2 locations incl. Greenville

Sponsor: East Carolina University

Sex: All·Age: 15 - 39

Code: NCT07173205·Recruiting

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EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN))

for Osteoarthritis

5 locations incl. Sacramento

Sponsor: DePuy Orthopaedics

Sex: All·Age: 21+

Code: NCT06631638·Recruiting

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A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Drug: Divarasib

50 locations incl. Anchorage

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06793215·Phase 3·Recruiting

Apply to this trial