Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos

Conditions

• Chaotic Aneuploidy
• Complex Aneuploidy

Eligibility Criteria

Sex

ALL

Age

N/A - N/A

Healthy Volunteers

Accepted

Study Details

This study aims to evaluate the reproductive potential of embryos classified as "complex aneuploid" (involving three or more abnormal chromosomes) or "chaotic" (six or more abnormal chromosomes) through preimplantation genetic testing for aneuploidy (PGT-A). Specifically, we seek to determine whether embryos initially reported as having multiple chromosomal abnormalities might still have the potential for normal chromosomal composition, the opportunity for transfer, and ultimately, the potential to achieve a live birth through re-biopsy and reanalysis. Key Information: This portion of the study seeks your consent for the re-biopsy and genetic reanalysis of the embryos only. It does not yet include consent for potential future transfer. Participation remains completely voluntary, and your decision will not affect your current or future care. We deeply appreciate your support and commitment to advancing fertility research.

Key Dates

Start date

Nov 1, 2025

Status verified

Nov 2025

Primary completion

Apr 30, 2026

Completion

Jun 30, 2026

Study Design

Enrollment

280 participants (estimated)

Arms

• Arm: Multiple Aneuploidy Embryos
  Embryos identified by PGT-A as having multiple chromosomal aneuploidies. DNA from trophectoderm re-biopsy samples will be retained by the testing laboratory for confirmatory analysis and quality control under IRB-approved protocols.

Primary Outcome Measure

Reproducibility [ Time Frame: one year ]

Central Contacts

• SGF Research Team SGF Research Team
  (301) 545-1423
  [email protected]
• Benjamin S Harris, MD, MPH
  [email protected]

Locations (11)

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