Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain

Part of paid clinical trials in Durham, North Carolina.

Sponsor
Duke University
Study ID
NCT06983678
Status
Recruiting
Apply to this trial

Conditions

  • Chronic Pain
  • Tobacco Use

Eligibility Criteria

Sex
ALL
Age
21 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Smoking as usual fMRI session — BEHAVIORAL
    Participants in this condition will continue smoking as usual prior to the fMRI session
  • Abstinent fMRI session — BEHAVIORAL
    Participants in this condition will be asked to abstain from smoking or using any other tobacco products for 24 hours prior to the fMRI session

Study Details

Individuals with chronic pain are more likely to smoke cigarettes and have more difficulty quitting smoking than the general population, in part because withdrawal from smoking can lead to temporary increases in pain. This research will examine how smoking withdrawal changes the way the brain processes pain, and whether these withdrawal-related changes interfere with the ability to stop smoking. The results of this research will provide important information that can be used to guide the development of interventions to help people with chronic pain who smoke cigarettes to quit smoking and improve their health.

Key Dates

Start date
Nov 4, 2025
Status verified
Nov 2025
Primary completion
Mar 31, 2030
Completion
Mar 31, 2030

Study Design

Enrollment
132 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Participants with chronic pain - Smoking as usual fMRI session first followed by Abstinent fMRI
    Participants with chronic pain randomized to complete a smoking as usual fMRI session followed by an Abstinent fMRI session.
  • Experimental: Participants with chronic pain - Abstinent fMRI session first followed by Smoking as usual fMRI
    Participants with chronic pain randomized to complete an Abstinent fMRI session followed by a smoking as usual fMRI session.
  • Experimental: Participants without chronic pain - Smoking as usual fMRI session first followed by Abstinent fMRI
    Participants without chronic pain randomized to complete a smoking as usual fMRI session followed by an Abstinent fMRI session.
  • Experimental: Participants without chronic pain - Abstinent fMRI session first followed by Smoking as usual fMRI
    Participants without chronic pain randomized to complete an Abstinent fMRI session followed by a smoking as usual fMRI session.

Primary Outcome Measure

Pain intensity ratings to high heat vs neutral temperatures [ Time Frame: Measured at each fMRI session (up to 1.5 hours) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Duke North PavilionDurhamNorth Carolina27705
Clinical Research Coordinator
[email protected]
984-209-9816

Find similar trials in Durham, NC

By research site
Duke North Pavilion· Durham, NC

Related Studies