A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

Part of paid clinical trials in Sacramento, California.

Sponsor
Pfizer
Study ID
NCT07073820
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

  • Pulmonary Hypertension

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • PF-07868489 — DRUG
    Participants will receive subcutaneous doses of PF-07868489 every 4 weeks

Study Details

The purpose of this study is to learn about the long-term safety, tolerability and effects of the study medicine (PF-07868489) for the possible treatment of PAH. PAH is a condition in which there is high blood pressure in the arteries that carry blood from the heart to the lungs. This high pressure makes it harder for the heart to pump blood through those lungs, potentially damaging the right side of the heart. This is an open-label study. Which means that both the healthcare providers and the study participants are aware of the medicine being given. This study is also an extension study with study medicine (PF-07868489). An extension study allows patients from an earlier clinical study (also called as qualifying study) to continue participating to assess long-term benefits and safety of the medicine.

Key Dates

Start date
Nov 10, 2025
Status verified
May 2026
Primary completion
Jul 18, 2028
Completion
Jul 18, 2028

Study Design

Enrollment
36 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Open Label
    Participants will receive subcutaneous doses of PF-07868489 every 4 weeks

Primary Outcome Measure

Number of Participants with Treatment Emergent Adverse Events (AEs) and Serious Adverse Events (SAEs) [ Time Frame: Baseline up to week 111 ]

Central Contacts

Locations (13)

FacilityCityStateZIPSite coordinators
UC Davis Health Medical CenterSacramentoCalifornia95817-
Heart and Vascular CenterSan FranciscoCalifornia94143-
UCSF Health St. Mary's HospitalSan FranciscoCalifornia94117-
University of Colorado Anschutz Medical CampusAuroraColorado80045-
Norton HospitalLouisvilleKentucky40202-
Norton Pulmonary SpecialistsLouisvilleKentucky40202-
Mount Sinai HospitalNew YorkNew York10029-
Clinical Trials Unit at Eastowne Medical Office BuildingChapel HillNorth Carolina27514-
Pulmonary Hypertension Clinical Trials Office at EastowneChapel HillNorth Carolina27514-
Pulmonary Specialty Clinic at Eastowne Medical Office BuildingChapel HillNorth Carolina27514-
UNC HospitalsChapel HillNorth Carolina27514-
Center for Advanced Lung CareProvidenceRhode Island02904-
Rhode Island HospitalProvidenceRhode Island02903-

Find similar trials in Sacramento, CA

By research site
UC Davis Health Medical Center· Sacramento, CAHeart and Vascular Center· San Francisco, CAUCSF Health St. Mary's Hospital· San Francisco, CAUniversity of Colorado Anschutz Medical Campus· Aurora, CONorton Hospital· Louisville, KYNorton Pulmonary Specialists· Louisville, KY

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