Paid Clinical Trials in North Carolina

North Carolina has 2,930 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,930 clinical trials

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A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant

for Multiple Myeloma

Drug: Daratumumab

17 locations incl. Scottsdale

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07095452·Phase 2, Phase 3·Recruiting

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SafeHeal Colovac Anastomosis Protection Device Evaluation Pivotal Study

for Colorectal Cancer

12 locations incl. Los Angeles

Sponsor: SafeHeal Inc

Sex: All·Age: 22+

Code: NCT07116668·Enrolling By Invitation

Lead Evaluation for Defibrillation and Reliability Post Approval Study

for Tachyarrhythmia

46 locations incl. Birmingham

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT07005232·Enrolling By Invitation

The ArtixASCEND Study

for Acute Lower Limb Arterial Occlusion

14 locations incl. New Haven

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT07135895·Recruiting

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Assessing and Addressing Health-Related Social Needs Among Families of Children With Cancer

for Childhood Cancers

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07278414·Recruiting

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Sensory Spinal Cord Stimulation

for Pain Management

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 85

Code: NCT07095036·Recruiting

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Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2

for Aging

4 locations incl. Derby

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07166861·Recruiting

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A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)

for Sickle Cell Disease

7 locations incl. Birmingham

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT07187973·Phase 1·Recruiting

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Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

for Advanced Non-Small Cell Lung Cancer

Drug: PF-08634404

184 locations incl. Bullhead City

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07222566·Phase 3·Recruiting

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Low Energy Availability and Hypertension in Division I HBCU Athletes

for Vascular Stiffness

1 location in Greensboro

Sponsor: North Carolina Agriculture & Technical State University

Sex: All·Age: 18 - 26·Accepts healthy volunteers

Code: NCT07583940·Recruiting

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A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

for Major Depressive Disorder

32 locations incl. Phoenix

Sponsor: Syndeio Biosciences, Inc

Sex: All·Age: 18 - 64

Code: NCT07115329·Phase 2·Recruiting

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Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

11 locations incl. Fullerton

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT07217587·Phase 3·Recruiting

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A Study to Learn About the Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Late Isolated Microvascular Inflammation

for Microvascular Inflammation

18 locations incl. Loma Linda

Sponsor: Biogen

Sex: All·Age: 18 - 74

Code: NCT07219043·Phase 2·Recruiting

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Beeline: A Phase 3 Study in GRIN-related Neurodevelopmental Disorder

for GRIN-related Neurodevelopmental Disorder

17 locations incl. Los Angeles

Sponsor: GRIN Therapeutics, Inc.

Sex: All·Age: 1 Month - 18

Code: NCT07224581·Phase 3·Recruiting

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A Study of a Decision Tool for People Considering Breast Reconstruction Surgery

for Breast Cancer

8 locations incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT07335354·Recruiting

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A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

for Metastatic Non-small Cell Lung Cancer With MTAP Deletion

Drug: Navlimetostat

42 locations incl. Anchorage

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07063745·Phase 2, Phase 3·Recruiting

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Yoga for Treatment of Overactive Bladder in Pediatric Patients

for Overactive Bladder

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 8 - 18

Code: NCT05895045·Recruiting

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Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

for Breast Cancer

4 locations incl. Bethesda

Sponsor: University Hospital, Basel, Switzerland

Sex: All·Age: 18+

Code: NCT07140172·Recruiting

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Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

30 locations incl. Birmingham

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting

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A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

for Untreated, Unresectable, or Metastatic Colorectal Cancer

Drug: Bevacizumab

49 locations incl. Tucson

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221357·Phase 2, Phase 3·Recruiting

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Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial

for Acute Respiratory Failure

16 locations incl. Los Angeles

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07223762·Enrolling By Invitation

Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.

for Diabetes (DM)

1 location in Durham

Sponsor: David D'Alessio, M.D.

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07224334·Phase 1·Recruiting

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Efficacy and Safety of KAI-9531 Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

for Obesity

Drug: Semaglutide

26 locations incl. Glendale

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284979·Phase 3·Recruiting

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Post-Market Study of the Signia Circular Stapler With Tri-Staple Technology in Left-sided Colon, Sigmoid, and Rectal Resections

for Colorectal Anastomosis

8 locations incl. New Haven

Sponsor: Medtronic - MITG

Sex: All·Age: 18+

Code: NCT07351071·Recruiting

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Optimizing Pain Treatment in Children On Mechanical Ventilation

for Mechanical Ventilation

15 locations incl. Little Rock

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 2 Months - 17

Code: NCT06994442·Phase 3·Recruiting

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A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis

for Atopic Dermatitis

Drug: Tapinarof

37 locations incl. Birmingham

Sponsor: Organon and Co

Sex: All·Age: 3 Months - 23 Months

Code: NCT07265479·Phase 3·Recruiting

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Diagnosing Epilepsy To EffeCT Change

for Epilepsy

18 locations incl. Phoenix

Sponsor: Epiminder America, Inc.

Sex: All·Age: 18 - 75

Code: NCT07110337·Recruiting

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A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease

for Degenerative Disc Disease

14 locations incl. Birmingham

Sponsor: DiscGenics, Inc.

Sex: All·Age: 18 - 75

Code: NCT07254806·Phase 3·Recruiting

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A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

for Breast Neoplasms

117 locations incl. Anchorage

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07174336·Phase 3·Recruiting

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A Study to Evaluate Safety, Tolerability and Pharmacokinetics of MNKD-201 in Patients With Idiopathic Pulmonary Fibrosis

for Idiopathic Pulmonary Fibrosis (IPF)

9 locations incl. Fresno

Sponsor: Mannkind Corporation

Sex: All·Age: 40 - 85

Code: NCT07344558·Phase 1·Recruiting

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Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy

for Obesity

13 locations incl. Northridge

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07225686·Phase 3·Recruiting

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A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy

for Spinal Muscular Atrophy (SMA)

17 locations incl. Little Rock

Sponsor: argenx

Sex: All·Age: 5 - 17

Code: NCT07287982·Phase 2·Recruiting

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Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

for Obesity and Overweight

35 locations incl. Scottsdale

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07311850·Phase 3·Recruiting

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A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

for Human Immunodeficiency Virus Type 1 (HIV-1) Infection

24 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07266831·Phase 2, Phase 3·Recruiting

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Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

for Obesity

23 locations incl. Anniston

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284875·Phase 3·Recruiting

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REVerse Intestinal Metaplasia in the Stomach (REVISE)

for Gastric Intestinal Metaplasia

1 location in Durham

Sponsor: Katherine Garman

Sex: All·Age: 18+

Code: NCT06590454·Phase 2·Recruiting

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REAL-Fam Feasibility Study for Youth Diabetes Management

for Type 1 Diabetes

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 2 - 99·Accepts healthy volunteers

Code: NCT07212790·Recruiting

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A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

for Overweight

Drug: Eloralintide

60 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07282600·Phase 3·Recruiting

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A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compared to Refresh Optive Unit Dose in Adult Participants With Dry Eye Disease

for Dry Eye Disease

20 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07284381·Phase 3·Recruiting

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A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)

for Metabolic Dysfunction-associated Steatohepatitis

58 locations incl. Chandler

Sponsor: Eccogene

Sex: All·Age: 18 - 75

Code: NCT07288138·Phase 2·Recruiting

Apply to this trial