Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial

Part of paid clinical trials in Los Angeles, California.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT07223762
Status
Enrolling By Invitation

Conditions

  • Acute Respiratory Failure

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Hyperangulated video laryngoscope blade — OTHER
    Hyperangulated video laryngoscope blade
  • Standard geometry video laryngoscope blade — OTHER
    Standard geometry video laryngoscope blade

Study Details

The Hyperangulated versus Standard Geometry Laryngoscope Blade (ANGLE) Trial is a multi-center, non-blinded, parallel-group, randomized clinical trial evaluating the effect of use of a hyperangulated video laryngoscope blade versus use of a standard geometry video laryngoscope blade. Critically ill adults undergoing tracheal intubation in participating EDs and ICUs who meet eligibility criteria will be enrolled and randomly assigned in a 1:1 ratio to either intubation using a hyperangulated video laryngoscope blade or a standard geometry video laryngoscope blade. The primary outcome is the incidence of successful intubation on the first attempt. The secondary outcome is incidence of hypoxemia during the interval between induction and 2 minutes after tracheal intubation.

Key Dates

Start date
Dec 30, 2025
Status verified
Jan 2026
Primary completion
Apr 30, 2027
Completion
May 31, 2027

Study Design

Enrollment
2,500 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Hyperangulated video laryngoscope blade
    For patients assigned to the hyperangulated video laryngoscope blade group, the operator will use a hyperangulated video laryngoscope blade on the first laryngoscopy attempt.
  • Active Comparator: Standard Geometry Video Laryngoscope Blade Group
    For patients assigned to the standard geometry laryngoscope blade group, the operator will use a standard geometry video laryngoscope blade on the first laryngoscopy attempt.

Primary Outcome Measure

Successful intubation on the first attempt. [ Time Frame: Duration of placement of the endotracheal tube, an average duration of two minutes. ]

Locations (16)

FacilityCityStateZIPSite coordinators
University of California, Los AngelesLos AngelesCalifornia90095-
Stanford UniversityStanfordCalifornia94305-
Denver Health Medical CenterDenverColorado80204-
University of Colorado, Denver Anschutz Medical CampusDenverColorado80045-
Rush University Medical CenterChicagoIllinois60612-
Our Lady of the Lake Hospital, Inc.Baton RougeLouisiana70808-
Ochsner Clinic FoundationJeffersonLouisiana70121-
University of Maryland BaltimoreBaltimoreMaryland21201-
Lahey Clinic, IncBurlingtonMassachusetts01805-
Hennepin Healthcare component - Hennepin County Medical CenterMinneapolisMinnesota55415-
Duke University Medical CenterDurhamNorth Carolina27710-
Wake Forest University Health SciencesWinston-SalemNorth Carolina27109-
The Ohio State UniversityColumbusOhio43210-
Oregon Health & Science UniversityPortlandOregon97239-
Vanderbilt University Medical CenterNashvilleTennessee37232-
Baylor Scott & White Research InstituteDallasTexas75201-

Find similar trials in Los Angeles, CA

By research site
University of California, Los Angeles· Los Angeles, CAStanford University· Stanford, CADenver Health Medical Center· Denver, COUniversity of Colorado, Denver Anschutz Medical Campus· Denver, CORush University Medical Center· Chicago, ILOur Lady of the Lake Hospital, Inc.· Baton Rouge, LA

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