Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Pfizer
Study ID
NCT07311850
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

  • Obesity and Overweight

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • MET097 — DRUG
    Once-weekly MET097 administered via subcutaneous injection
  • Placebo — DRUG
    Once-weekly placebo administered via subcutaneous injection

Study Details

This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.

Key Dates

Start date
Dec 19, 2025
Status verified
Jun 2026
Primary completion
Sep 21, 2027
Completion
Apr 25, 2028

Study Design

Enrollment
3,501 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: MET097 Dose 1
    Participants will receive MET097 administered subcutaneously
  • Experimental: MET097 Dose 2
    Participants will receive MET097 administered subcutaneously
  • Experimental: MET097 Dose 3
    Participants will receive MET097 administered subcutaneously
  • Placebo Comparator: Placebo
    Once-weekly placebo administered via subcutaneous injection

Primary Outcome Measure

Percent change from baseline in body weight [ Time Frame: Baseline (Day 0) to Week 64 ]

Central Contacts

Locations (35)

FacilityCityStateZIPSite coordinators
Headlands ResearchScottsdaleArizona85260-
Alliance Research InstituteCanoga ParkCalifornia91304-
Collaborative Neuroscience Research, LLCGarden GroveCalifornia92845-
Clinical Innovations, Inc dba CITrialsRiversideCalifornia92506-
Peninsula Headlands LLCRolling HillsCalifornia90274-
CenExcel Rocky Mountain Clinical Research, LLCEnglewoodColorado80113-
Research Centers of AmericaHollywoodFlorida33024-
Future Medical Research (Civia Health)LongwoodFlorida32750-
Advanced Clinical ResearchMiamiFlorida33156-
Oviedo Medical ResearchOviedoFlorida32765-
CenExel FCR - ForCare Clinical ResearchTampaFlorida33613-
DelRicht Research @ Springer Wellness and Restorative HealthAtlantaGeorgia30329-
CenExel iResearch, LLCSavannahGeorgia31405-
CenExel CBH HealthGaithersburgMaryland20877-
Clinical Research ProfessionalsChesterfieldMissouri63005-
Civia Health St. LouisCreve CoeurMissouri63141-
Civia Health IndependenceIndependenceMissouri64055-
Upgrade Performance InstituteElkhornNebraska68022-
Quality Clinical Research IncOmahaNebraska68114-
Primary Care Research (Civia Health)PapillionNebraska68046-
CenExel HRI - Hassman Research InstituteMarltonNew Jersey08053-
Forum Health CaryCaryNorth Carolina27511-
Eximia EquiHealth ResearchDurhamNorth Carolina27704-
TMA Headlands LLCWilmingtonNorth Carolina28403-
Summit Headlands LLCPortlandOregon97210-
Tribe Clinical Research, LLCGreenvilleSouth Carolina29607-
Tribe Clinical Research, LLCSpartanburgSouth Carolina29301-
Civia Health GoodlettsvilleGoodlettsvilleTennessee37072-
Civia Health NashvilleLa VergneTennessee37086-
Civia Health MemphisMemphisTennessee38117-
Forum Austin (Civia Health)AustinTexas78758-
Cedar Health ResearchDallasTexas75251-
GLRI El Paso ResearchEl PasoTexas79936-
Dallas Clinical Research Center (Pillar Clinical Research)RichardsonTexas75080-
Pantheon Clinical ResearchBountifulUtah84010-

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By research site
Headlands Research· Scottsdale, AZAlliance Research Institute· Canoga Park, CACollaborative Neuroscience Research, LLC· Garden Grove, CAClinical Innovations, Inc dba CITrials· Riverside, CAPeninsula Headlands LLC· Rolling Hills, CACenExcel Rocky Mountain Clinical Research, LLC· Englewood, CO

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