Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure

for Obesity

1 location in Boston

Sponsor: Christopher C. Thompson, MD, MSc

Sex: All·Age: 18 - 70

Code: NCT05711758·Recruiting

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An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer

for Rectal Cancer

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05914766·Recruiting

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PET/MRI/EEG Imaging Study in Epilepsy

for Epilepsy

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06974305·Recruiting

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LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease

for Liver Disease Chronic

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05998330·Recruiting

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A Study of D3L-001 as Monotherapy in Subjects With HER2-Positive Advanced Solid Tumors

for HER-2 Positive Advanced Solid Tumors

4 locations incl. Stanford

Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All·Age: 18+

Code: NCT05957536·Phase 1·Recruiting

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MCT for the Harvard/UCSF ROBIN Center

for Glioma, Childhood Brainstem

2 locations incl. San Francisco

Sponsor: Brigham and Women's Hospital

Sex: All·Age: All ages

Code: NCT06000787·Recruiting

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Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

for Lumbar Spinal Stenosis

6 locations incl. Beverly Hills

Sponsor: Columbia University

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06034405·Recruiting

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CorEvitas Generalized Pustular Psoriasis (GPP) Drug Safety and Effectiveness Registry

for Generalized Pustular Psoriasis

1 location in Waltham

Sponsor: CorEvitas

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06100991·Recruiting

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CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting

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Efficacy in Controlling Myopia in Young Children Using a Novel Spectacle Lens

for Myopia

14 locations incl. Oakland

Sponsor: SightGlass Vision, Inc.

Sex: All·Age: 6 - 8·Accepts healthy volunteers

Code: NCT06034327·Recruiting

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Gene Therapy Trial for Otoferlin Gene-mediated Hearing Loss

for Sensorineural Hearing Loss, Bilateral

6 locations incl. San Francisco

Sponsor: Akouos, Inc.

Sex: All·Age: All ages

Code: NCT05821959·Phase 1, Phase 2·Recruiting

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

955 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting

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Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

for Non-muscle Invasive Bladder Cancer

40 locations incl. Homewood

Sponsor: Protara Therapeutics

Sex: All·Age: 18+

Code: NCT05951179·Phase 2·Recruiting

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IKS014 in Advanced Solid Tumors That Express HER2

for Breast Cancer

4 locations incl. Newport Beach

Sponsor: Iksuda Therapeutics Ltd.

Sex: All·Age: 18+

Code: NCT05872295·Phase 1·Recruiting

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Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

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A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

for Systemic Lupus Erythematosus

31 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT05869955·Phase 1·Recruiting

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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

for Surgery-Complications

20 locations incl. Little Rock

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05991453·Recruiting

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Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

for Delirium, Postoperative

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 70+

Code: NCT06052397·Recruiting

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Cryoablation for Monomorphic Ventricular Tachycardia

for Sustained VT

13 locations incl. Phoenix

Sponsor: Adagio Medical

Sex: All·Age: 18+

Code: NCT05675865·Recruiting

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Mechanisms of Open and Hidden Placebo in Stroke Recovery

for Stroke

1 location in Cambridge

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18+

Code: NCT05832567·Recruiting

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Comparison of Uncomplicated Candidemia Therapy Duration in Children

for Invasive Candidiasis

21 locations incl. Birmingham

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days+

Code: NCT05763251·Recruiting

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A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

for Metastatic Breast Cancer

20 locations incl. Gilbert

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT05894239·Phase 3·Recruiting

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To Compare the Efficacy and Safety of the ATEV With AVF in Female Patients With End-Stage Renal Disease Requiring Hemodialysis

for End Stage Renal Disease (ESRD)

32 locations incl. Scottsdale

Sponsor: Humacyte, Inc.

Sex: Female·Age: 18+

Code: NCT05908084·Phase 3·Recruiting

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Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

for Non-small Cell Lung Cancer (NSCLC)

17 locations incl. Sacramento

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06040541·Phase 1·Recruiting

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Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and Compensated Cirrhosis

for Primary Biliary Cholangitis

49 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06051617·Phase 3·Recruiting

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Lung Cancer Screening in High-risk Black Individuals

for Lung Cancer

2 locations incl. Chicago

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT05898594·Recruiting

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A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

for Small Cell Lung Cancer (SCLC)

12 locations incl. Duarte

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05652686·Phase 1, Phase 2·Recruiting

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A Gene Therapy Study of RP-A501 in Male Patients With Danon Disease

for Danon Disease

3 locations incl. La Jolla

Sponsor: Rocket Pharmaceuticals Inc.

Sex: Male·Age: 8+

Code: NCT06092034·Phase 2·Recruiting

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A Brief Values Intervention to Support Veterans in Early Buprenorphine Treatment

for Dependence, Opioid

1 location in Bedford

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05189223·Recruiting

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Adjunctive Motivational Alcohol Intervention to Prevent IPV

for Alcohol Use and Intimate Partner Violence

3 locations incl. Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05287711·Recruiting

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SPEARHEAD-3 Pediatric Study

for Synovial Sarcoma

10 locations incl. Palo Alto

Sponsor: USWM CT, LLC

Sex: All·Age: 2 - 21

Code: NCT05642455·Phase 1, Phase 2·Recruiting

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The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes

for Cystic Fibrosis

2 locations incl. Boston

Sponsor: Rhode Island Hospital

Sex: All·Age: 18 - 70

Code: NCT05723445·Recruiting

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Cerebellar TMS and Satiety in Prader-Willi Syndrome

for Prader-Willi Syndrome

1 location in Belmont

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 64

Code: NCT05938543·Recruiting

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Enhancing Equity in Smoke-free Housing

for Tobacco Use

1 location in Boston

Sponsor: Harvard School of Public Health (HSPH)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06042361·Enrolling By Invitation

Telehealth and Onsite Maintenance Exercise in Chronic Lung Disease

for Copd

1 location in Charlestown

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 40+

Code: NCT06304207·Recruiting

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The Function of Biphasic Sleep in Infants

for Sleep Deprivation

1 location in Amherst

Sponsor: University of Massachusetts, Amherst

Sex: All·Age: 9 Months - 15 Months·Accepts healthy volunteers

Code: NCT06399939·Recruiting

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EpiFaith Resident Learning Curve Trial

for Epidural Analgesia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07395622·Enrolling By Invitation

Ultrasound Therapy In Cardiac Amyloidosis

for Amyloidosis Cardiac

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04667494·Phase 4·Recruiting

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Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth In/near Infected Bone Cavities

for Periprosthetic Joint Infections

12 locations incl. Los Angeles

Sponsor: Elute, Inc.

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT05361941·Recruiting

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Screening Trial for Pain Relief in Schwannomatosis (STARFISH)

for Schwannomatosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05684692·Phase 2·Recruiting

Apply to this trial