Cerebellar TMS and Satiety in Prader-Willi Syndrome

Part of paid clinical trials in Belmont, Massachusetts.

Sponsor
Brigham and Women's Hospital
Study ID
NCT05938543
Status
Recruiting
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Conditions

  • Prader-Willi Syndrome

Eligibility Criteria

Sex
ALL
Age
18 Years - 64 Years
Healthy Volunteers
Not accepted

Interventions

  • Repetitive Transcranial Magnetic Stimulation (rTMS) — DEVICE
    rTMS is a technique of TMS that allows for selective external manipulation of neural activity in a non-invasive manner. During rTMS a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field, which in turn induces an electrical current in neurons and allows for modulation of neural circuitry. Other Name: iTBS

Study Details

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to study hyperphagia and satiety in Prader-Willi syndrome. TMS is a noninvasive way of stimulating the brain, using a magnetic field to change activity in the brain. The magnetic field is produced by a coil that is held next to the scalp. In this study, the investigators will be stimulating the brain to learn more about how TMS might improve hyperphagia in Prader-Willi syndrome.

Key Dates

Start date
Sep 1, 2023
Status verified
Dec 2025
Primary completion
Sep 30, 2026
Completion
Oct 31, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Active cerebellum rTMS
    Cerebellar targeted iTBS, once daily, one week

Primary Outcome Measure

Retention of subjects in study assessments [ Time Frame: 1-week post-TMS follow-up visit ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
McLean HospitalBelmontMassachusetts02478
Mark Halko, PhD
[email protected]

Find similar trials in Belmont, MA

By research site
McLean Hospital· Belmont, MA

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