Ultrasound Therapy In Cardiac Amyloidosis

Part of paid clinical trials in Boston, Massachusetts.

Sponsor
Brigham and Women's Hospital
Study ID
NCT04667494
Phase
PHASE4
Status
Recruiting
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Conditions

  • Amyloidosis Cardiac

Eligibility Criteria

Sex
ALL
Age
18 Years - 90 Years
Healthy Volunteers
Accepted

Interventions

  • Sonotherapy — COMBINATION_PRODUCT
    Use of high mechanical index ultrasound therapy with intravenous Definity contrast infusion

Study Details

This is a prospective pilot clinical study of subjects with cardiac amyloidosis and control subjects without amyloidosis where we plan to evaluate changes in myocardial blood flow, systolic and diastolic function before and after sonotherapy.

Key Dates

Start date
Aug 31, 2023
Status verified
Nov 2025
Primary completion
Apr 30, 2026
Completion
Apr 30, 2027

Study Design

Enrollment
70 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Sonotherapy
    All participants will undergo sonotherapy

Primary Outcome Measure

Myocardial Blood Flow [ Time Frame: 1 day ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Brigham and Women's HospitalBostonMassachusetts02115
Sharmila Dorbala, MBBS, MPH
[email protected]
617-732-6290
Sharmila Dorbala, MBBS, MPH (PRINCIPAL_INVESTIGATOR)

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By research site
Brigham and Women's Hospital· Boston, MA

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