Intracardiac Flow Assessment in Cardiac Amyloidosis

Conditions

• Amyloidosis Cardiac
• Healthy Adults

Eligibility Criteria

Sex

ALL

Age

40 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Cardiac magnetic resonance image (CMR) — DIAGNOSTIC_TEST
  A magnetic resonance imaging study for assessment of cardiac structure and intracardiac flow
• Transthoracic Echocardiogram (TTE) — DIAGNOSTIC_TEST
  An imaging test that uses soundwaves that cannot be heard (ultrasound) to take pictures of the heart and vessels.
• Six-minute Walk Test — DIAGNOSTIC_TEST
  A self-paced, test of exercise capacity performed unencouraged intensity that measures the distance that patients can walk on a flat, hard surface in a period of 6 minutes

Study Details

The primary objective of this study is to define the intracardiac flow imaging biomarkers in cardiac amyloidosis.

Key Dates

Start date

Jul 20, 2022

Status verified

Jul 2025

Primary completion

May 31, 2026

Completion

Jun 30, 2026

Study Design

Enrollment

100 participants (estimated)

Arms

• Arm: Transthyretin (ATTR) cardiac amyloidosis
  Subjects diagnosed with ATTR cardiac amyloidosis will have CMR, TTE, and 6-minute walk
• Arm: Light chain amyloidosis (AL) with cardiac involvement
  Subjects diagnosed with AL with cardiac involvement will have CMR, TTE, and 6-minute walk
• Arm: Light chain amyloidosis (AL) without cardiac involvement
  Subjects diagnosed with AL without cardiac involvement will have CMR, TTE, and 6-minute walk
• Arm: Healthy Control
  Subjects without history of cardiovascular diseases will have CMR, TTE, and 6-minute walk

Primary Outcome Measure

Define the intracardiac flow imaging biomarkers in cardiac amyloidosis (CA) [ Time Frame: Baseline ]

Central Contacts

• Kathy Brown
  507-538-1321
  [email protected]

Locations (1)

Find similar trials in Rochester, MN

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