Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Part of paid clinical trials in Sacramento, California.

Sponsor
Revolution Medicines, Inc.
Study ID
NCT06040541
Phase
PHASE1
Status
Recruiting
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Conditions

  • Advanced Solid Tumors
  • Colorectal Cancer (CRC)
  • Non-small Cell Lung Cancer (NSCLC)
  • Pancreatic Ductal Adenocarcinoma (PDAC)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • RMC-9805 — DRUG
    Oral Tablets
  • RMC-6236 — DRUG
    Oral Tablets

Study Details

This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.

Key Dates

Start date
Sep 7, 2023
Status verified
Jun 2026
Primary completion
Dec 31, 2026
Completion
Apr 30, 2027

Study Design

Enrollment
604 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: RMC-9805 monotherapy arm
    Dose exploration and dose expansion
  • Experimental: RMC-9805 plus RMC-6236 combination arm
    Dose exploration and dose expansion

Primary Outcome Measure

Adverse events [ Time Frame: Up to 3 years ]

Central Contacts

Locations (17)

FacilityCityStateZIPSite coordinators
University of California, Davis Comprehensive Cancer CenterSacramentoCalifornia95817-
Smilow Cancer Hospital (Yale University)New HavenConnecticut06511-
Florida Cancer SpecialistsSarasotaFlorida34232-
Lee Moffitt Cancer CenterTampaFlorida33612-
Johns Hopkins UniversityBaltimoreMaryland21287-
Dana-Farber Cancer InstituteBostonMassachusetts02215-
Massachusetts General HospitalBostonMassachusetts02114-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065-
NYU LangoneNew YorkNew York10016-
Duke Cancer CenterDurhamNorth Carolina27710-
Carolina BioOncology InstituteHuntersvilleNorth Carolina28078-
The Christ HospitalCincinnatiOhio45219-
Sarah Cannon Research InstituteNashvilleTennessee37203-
Sarah Cannon Research Institute at Mary CrowleyDallasTexas75230-
University of Texas, MD Anderson Cancer CenterHoustonTexas77030-
STARTSan AntonioTexas78229-
NEXT Oncology VirginiaFairfaxVirginia22031-

Find similar trials in Sacramento, CA

By research site
University of California, Davis Comprehensive Cancer Center· Sacramento, CASmilow Cancer Hospital (Yale University)· New Haven, CTFlorida Cancer Specialists· Sarasota, FLLee Moffitt Cancer Center· Tampa, FLJohns Hopkins University· Baltimore, MDDana-Farber Cancer Institute· Boston, MA

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