Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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Comparative Effectiveness of SPARCS and Unified Protocol for Youth With Chronic Medical Conditions and Trauma-Related Distress

for Trauma Exposure

1 location in Chicago

Sponsor: Anthony Vesco

Sex: All·Age: 8 - 18

Code: NCT07483333·Not Yet Recruiting

Aprepitant to Improve Same Day Discharge for TKA

for PONV

1 location in Skokie

Sponsor: Endeavor Health

Sex: All·Age: 18 - 90

Code: NCT07639723·Phase 4·Not Yet Recruiting

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain

for Chronic Pain

Drug: LY4065967

36 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07641504·Phase 2·Not Yet Recruiting

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

for Osteoarthritis, Knee

Drug: LY4065967

36 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 40+

Code: NCT07641517·Phase 2·Not Yet Recruiting

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

for Solid Tumors

18 locations incl. San Francisco

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07492680·Phase 2·Not Yet Recruiting

Research Investigating Drug Effects-2 (RiDE-2)

for Cannabis Use

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 21·Accepts healthy volunteers

Code: NCT06758596·EARLY_Phase 1·Not Yet Recruiting

Cabotegravir & Rilpivirine Antiretroviral Therapy in Pregnancy

for HIV -1 Infection

10 locations incl. La Jolla

Sponsor: International Maternal Pediatric Adolescent AIDS Clinical Trials Group

Sex: Female·Age: 18+

Code: NCT07637942·Not Yet Recruiting

A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer

for Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia

Drug: Tirzepatide

3 locations incl. Chicago

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT07349641·Phase 2·Not Yet Recruiting

Implementing A Secure Firearm Storage Program in Illinois Health Centers in Partnership With AllianceChicago and the Illinois Primary Health Care Association (COMMUNITY ASPIRE)

for Suicide

1 location in Springfield

Sponsor: Northwestern University

Sex: All·Age: All ages

Code: NCT06886776·Not Yet Recruiting

Evaluating the Efficacy of a Vocational Counseling Intervention to Improve Occupational Functioning and Employment Quality Among Veterans With Mental Health and Substance Use Disorders

for Unemployment

3 locations incl. Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07097376·Not Yet Recruiting

Effect of a Microprocessor-controlled Prosthetic Knee Joint on K2 Level Ambulators

for Transfemoral Amputation

2 locations incl. Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 45 - 85

Code: NCT07103798·Not Yet Recruiting

Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT

for Chronic Low Back Pain

2 locations incl. Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 22+

Code: NCT07158567·Phase 3·Not Yet Recruiting

Testing the SurVaxM Vaccine for Lung Cancer Prevention

for Lung Carcinoma

Drug: SurVaxM

4 locations incl. Aurora

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07169617·Phase 2·Not Yet Recruiting

Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial

for Metastatic Appendix Carcinoma

5 locations incl. Goodyear

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07271355·Phase 3·Not Yet Recruiting

COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE"

for New Onset Refractory Status Epilepticus

Drug: Tocilizumab

25 locations incl. Phoenix

Sponsor: Yale University

Sex: All·Age: 2+

Code: NCT07281027·Phase 3·Not Yet Recruiting

Implementation of AIP Services for Older Adults With AD

for Alzheimer Disease

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07361601·Not Yet Recruiting

Efficacy of Integrating Next Generation Sequencing for Treatment of Surgical Site Infection After Fracture Fixation:

for Next Generation Sequencing (NGS)

18 locations incl. Tuscaloosa

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 84

Code: NCT07458230·Phase 3·Not Yet Recruiting

Optimal Targeted High-definition Transcranial Direct Current Stimulation for Reducing Post-stroke Upper Limb Motor Impairments

for Hemiparetic Stroke

1 location in Urbana

Sponsor: Carle Foundation Hospital

Sex: All·Age: 18+

Code: NCT07599774·Not Yet Recruiting

BRIDGE-US: Bridging Readiness in Deployed Neurotrauma Gaps for Excellence

for Brain Injuries, Acute

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 16+

Code: NCT07636213·Not Yet Recruiting

Aripiprazole in Body Focused Repetitive Behaviors

for Trichotillomania (Hair-Pulling Disorder)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05545891·Phase 2·Not Yet Recruiting

Ruxolitinib and Enzalutamide for the Treatment of Metastatic Castration-Resistant Prostate Cancer

for Castration-Resistant Prostate Carcinoma

Drug: Ruxolitinib

3 locations incl. Chicago

Sponsor: University of Michigan Rogel Cancer Center

Sex: Male·Age: 18+

Code: NCT06616155·Phase 1, Phase 2·Recruiting

Apply to this trial

Study to Assess the Feasibility of Stopping Prostate Cancer Treatment Early in Elderly Patients

for Elderly

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: Male·Age: 70+

Code: NCT06824818·Recruiting

Apply to this trial

Study of the Pharmacokinetics and Safety of Glecaprevir/Pibrentasvir Initiated in Pregnancy in Women With Hepatitis C With and Without HIV

for Hepatitis C

Drug: Glecaprevir/pibrentasvir

10 locations incl. Los Angeles

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: Female·Age: 16 - 45

Code: NCT07040319·Phase 1, Phase 2·Recruiting

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A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

for Lymphoma, Non-Hodgkin

23 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07101328·Phase 1·Not Yet Recruiting

Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage

for Subarachnoid Hemorrhage

Drug: Nicardipine

1 location in Park Ridge

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07246629·Phase 4·Not Yet Recruiting

A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With HR+, HER2- Advanced Breast Cancer

for Advanced Breast Cancer

11 locations incl. Hot Springs

Sponsor: TerSera Therapeutics LLC

Sex: Female·Age: 18 - 55

Code: NCT07310420·Phase 1·Recruiting

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A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications

for Parkinson's Disease

26 locations incl. Phoenix

Sponsor: Bayer

Sex: All·Age: 45 - 75

Code: NCT07330258·Recruiting

Apply to this trial

RUSH Food is Medicine Veggie Rx - GusNIP Produce Prescription

for Food Insecurity

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07376044·Not Yet Recruiting

Study of GB-4362 With Enfortumab Vedotin and Pembrolizumab for Advanced Urothelial Cancer

for Advanced Urothelial Cancer

Drug: GB-4362

7 locations incl. Duarte

Sponsor: Generate Biomedicines

Sex: All·Age: 18+

Code: NCT07484022·Phase 1·Recruiting

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Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

for Pancreatic Cancer

Drug: Atebimetinib

12 locations incl. Phoenix

Sponsor: Immuneering Corporation

Sex: All·Age: 18+

Code: NCT07562152·Phase 3·Recruiting

Apply to this trial

Emsella for Reducing tSUI After HOLEP

for Benign Prostatic Hyperplasia

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 50 - 80·Accepts healthy volunteers

Code: NCT07580404·Not Yet Recruiting

A Post-Market Assessment of the Safety and Performance of the TriClip™ System

for Tricuspid Regurgitation (TR)

2 locations incl. La Jolla

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT07586995·Enrolling By Invitation

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

for Overweight

Drug: Eloralintide

40 locations incl. The Villages

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07589608·Phase 2·Not Yet Recruiting

VR Therapies for IBD

for Inflammatory Bowel Disease (IBD)

2 locations incl. Los Angeles

Sponsor: Brennan Spiegel

Sex: All·Age: 18+

Code: NCT07590518·Not Yet Recruiting

A Study in Adults With Geographic Atrophy

for Geographic Atrophy

20 locations incl. Bakersfield

Sponsor: Sitala Bio LTD

Sex: All·Age: 60+

Code: NCT07606365·Phase 2·Not Yet Recruiting

Parents and Babies Pilot

for Perinatal Depression

1 location in Chicago

Sponsor: Northwestern University

Sex: Female·Age: 18+

Code: NCT07607613·Not Yet Recruiting

A Study to Evaluate the Efficacy and Safety of Concomitant Use of Eplontersen and ALXN2220 Compared With Eplontersen and Placebo for Adults Participants With ATTR-CM

for Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

24 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18 - 85

Code: NCT07608354·Phase 2·Not Yet Recruiting

Azithromycin for Cerclage Prophylaxis

for Cervical Insufficiency

2 locations incl. Oak Lawn

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+

Code: NCT07608562·Phase 4·Not Yet Recruiting

A Study to Measure Mirikizumab Levels in Breast Milk of Lactating Participants Receiving Mirikizumab Therapeutically for an Approved Indication

for Lactation

5 locations incl. Glenview

Sponsor: Eli Lilly and Company

Sex: Female·Age: 3 Weeks+

Code: NCT07612267·Phase 4·Not Yet Recruiting

An International Multicenter, Multivendor Evaluation of the Free-Running Framework for Cardiac Function

for Congenital Heart Diseases

9 locations incl. Los Angeles

Sponsor: Matthias Stuber

Sex: All·Age: All ages

Code: NCT07613398·Not Yet Recruiting