Aripiprazole in Body Focused Repetitive Behaviors

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Chicago
Study ID
NCT05545891
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

  • Dermatillomania
  • Trichotillomania (Hair-Pulling Disorder)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Placebo — DRUG
    A drug that contains no medicine
  • Aripiprazole — DRUG
    Atypical antipsychotic medication

Study Details

This study is 6 weeks long and involves subjects taking aripiprazole or placebo. If they are randomly assigned to the aripiprazole arm and are eligible to participate in the study, they will begin by taking 5mg once daily of aripiprazole for two weeks, then 10mg once daily for the remaining three weeks. Efficacy and safety measures will be performed at each visit. Participants will be randomized to receive either aripiprazole or placebo on a 1:1 basis. This blinding will be maintained by the IDS pharmacy at the University of Chicago.

Key Dates

Start date
Jun 30, 2026
Status verified
Sep 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Placebo
    5mg once daily of placebo for three weeks, then 10mg once daily for the remaining three weeks.
  • Experimental: Aripiprazole
    5mg once daily of aripiprazole for three weeks, then 10mg once daily for the remaining three weeks.

Primary Outcome Measure

NIMH Symptom Severity Scale (for TTM or Skin Picking) [ Time Frame: The primary efficacy end points will be the change in these measures from baseline to week 6. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of ChicagoChicagoIllinois60637
Madison Collins, BA
[email protected]
773-834-3778
P
Jon E Grant, MD, JD, MPH (PRINCIPAL_INVESTIGATOR)

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