Research Investigating Drug Effects-2 (RiDE-2)

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Illinois at Chicago
Study ID
NCT06758596
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Cannabis Use
  • Healthy
  • Substance Use Disorder (SUD)

Eligibility Criteria

Sex
ALL
Age
18 Years - 21 Years
Healthy Volunteers
Accepted

Interventions

  • Placebo Oral Capsule — DRUG
    A capsule that contains only dextrose filler administered during the first or second laboratory visit.
  • THC — DRUG
    A capsule that contains 7.5 mg of THC as well as dextrose filler administered during the first or second laboratory visit.

Study Details

The purpose of this study is to better understand how people's mood, behavior, and brains respond to different recreational drugs. We are also trying to understand why some people may feel differently or their brain may respond differently than other people after taking the same recreational drug.

Key Dates

Start date
Jul 15, 2026
Status verified
Sep 2025
Primary completion
Mar 31, 2031
Completion
Jun 30, 2031

Study Design

Enrollment
144 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Placebo Comparator: Placebo oral capsule
    Participants will receive a placebo at their first or second laboratory visit.
  • Experimental: THC
    Participants will receive THC (7.5 mg) at their first or second laboratory visit.

Primary Outcome Measure

Recent Substance Use [ Time Frame: Baseline screening, baseline drug administration, and every 6 months over two years of follow-up ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Illinois at ChicagoChicagoIllinois60612
Natania Crane, PhD
[email protected]
312-413-4453

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By research site
University of Illinois at Chicago· Chicago, IL

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