Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

for Major Depressive Episode (MDE)

25 locations incl. Phoenix

Sponsor: Tonix Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07621237·Phase 2·Recruiting

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Ejaculatory-Sparing HoLEP vs Standard HoLEP

for Enlarged Prostate (BPH)

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07631286·Recruiting

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MAGNEsium With meToprolol for Rate Control In Atrial Fibrillation

for Atrial Flutter With Rapid Ventricular Response

1 location in Oak Lawn

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07632157·Phase 3·Not Yet Recruiting

Moses 2.0 vs Magneto for HoLEP - a Randomized Controlled Trial

for Enlarged Prostate (BPH)

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07632742·Recruiting

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A Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP)

for Primary Immune Thrombocytopenia (ITP)

Drug: Ianalumab

2 locations incl. Margate

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07421167·Phase 2·Recruiting

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A Study Evaluating the Immunotherapy Treatment for Ovarian Cancer and Other Advanced Malignancies.

for Ovarian Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07389239·Phase 1, Phase 2·Not Yet Recruiting

A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight

for Overweight

26 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07357766·Phase 3·Not Yet Recruiting

A Study to Test Whether Nerandomilast Helps People With Systemic Sclerosis

for Systemic Sclerosis

Drug: Nerandomilast

30 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07497087·Phase 3·Not Yet Recruiting

Spiritual Care Intervention in Adult Patients Diagnosed With Acute Leukemia

for Leukemia

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07405424·Recruiting

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A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection

for HIV-1-infection

10 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT06987318·Phase 1·Not Yet Recruiting

A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity

for Obesity

Drug: NNC0662-0419

24 locations incl. Montgomery

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07639021·Phase 2·Not Yet Recruiting

Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer

for Advanced Clear Cell Renal Cell Carcinoma

41 locations incl. Fayetteville

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT07383441·Phase 3·Recruiting

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MINT Conditioning to Improve Gait

for Stroke

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT07041775·Recruiting

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Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury

for Nonsuicidal Self-injury

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 14 - 18

Code: NCT07224165·Recruiting

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A Study of Lirafugratinib in Non-CCA Solid Tumors With FGFR2 Fusion or Rearrangement

for FGFR2 Gene Fusion/Rearrangement

Drug: Lirafugratinib

7 locations incl. Phoenix

Sponsor: Elevar Therapeutics

Sex: All·Age: 18+

Code: NCT07359820·Phase 2·Recruiting

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GBPDC: Gut-Brain in PD Consortium Master Protocol

for Parkinson Disease (PD)

7 locations incl. Stanford

Sponsor: Duke University

Sex: All·Age: 21 - 80·Accepts healthy volunteers

Code: NCT07567794·Not Yet Recruiting

A RCT of Spectacles With Aspherical Lenslets or 0.05% Atropine for Myopia Control

for Myopia

12 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 5 - 11

Code: NCT07095894·Phase 3·Recruiting

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PREcision MEDicine In Achalasia (PREMEDIA) - Cohort

for Type III Achalasia

13 locations incl. Scottsdale

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07293689·Recruiting

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Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms

for Postpartum Depression (PPD)

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18+

Code: NCT07485036·Not Yet Recruiting

Symbiotic-Lung-10: A Study to Learn About PF-08634404 Alone or in Combination in Early-stage or Locally Advanced NSCLC

for Carcinoma

Drug: PF-08634404

2 locations incl. Hinsdale

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07489066·Phase 2·Recruiting

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Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System

for Opiod Use Disorder

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07498322·Not Yet Recruiting

A Phase 2 Clinical Study to Evaluate the Efficacy and Safety of Frevecitinib (KN-002) in Patients With Severe Asthma

for Severe Asthma

Drug: Frevecitinib

15 locations incl. Lancaster

Sponsor: Kinaset Therapeutics Inc

Sex: All·Age: 18 - 75

Code: NCT07532265·Phase 2·Not Yet Recruiting

Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males

for Inguinal Hernia Unilateral

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: 50+

Code: NCT07604272·Phase 1·Not Yet Recruiting

Tailor VHA HH Bundle for Acute Mental Health Care

for Hand Hygiene Compliance

4 locations incl. Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 90

Code: NCT07607145·Recruiting

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The Implementation of Genetic Risk for Colorectal Cancer Screening

for Colorectal Cancer

1 location in Evanston

Sponsor: Endeavor Health

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07621757·Enrolling By Invitation

Food and Metabolism Study

for Prediabetes

1 location in Chicago

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Sex: All·Age: 40 - 70·Accepts healthy volunteers

Code: NCT07624500·Not Yet Recruiting

Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites

for Nicotine Use Disorder

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 26

Code: NCT06837220·Recruiting

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Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines

for Posttraumatic Osteoarthritis

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 50

Code: NCT07142369·Not Yet Recruiting

CARE Tool Study Aim 3

for Gynecologic Cancer

3 locations incl. Alton

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07296887·Recruiting

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The Effect of Apple Cider Vinegar Supplementation on 24-hour Urine Chemistry in Adults

for Kidney Stones

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07389226·Not Yet Recruiting

Can 3D Modeling Enhance Patient Understanding, Education, and Surgical Outcomes in Gender Affirming Peritoneal Vaginoplasty?

for Vaginoplasty

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT07412509·Not Yet Recruiting

Outpatient Visits Versus Telehealth for Postoperative Care After Minimally Invasive Gynecologic Surgery

for to Determine Whether Patient Satisfaction With Postoperative Telehealth Follow-up is Non-inferior to In-person Clinic Visits

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: Female·Age: 18+

Code: NCT07420114·Not Yet Recruiting

The FLOW Registry.

for Benign Prostatic Hyperplasia (BPH)

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT07430423·Not Yet Recruiting

Utilizing Electronic Modules to Educate on Sexual Health Practices During Pregnancy

for Sexual Health Education During Pregnancy

1 location in Maywood

Sponsor: Loyola University

Sex: Female·Age: 18+

Code: NCT07497971·Not Yet Recruiting

Vaginal Sildenafil for Primary Dysmenorrhea

for Dysmenorrhea

1 location in Evanston

Sponsor: Kevin Hellman

Sex: Female·Age: 18 - 35

Code: NCT07508358·Phase 1·Not Yet Recruiting

Genicular Artery Embolization for Knee Osteoarthritis

for Osteoarthritis

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 40 - 80

Code: NCT07537153·Recruiting

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GI-05: The Impact of Olanzapine Among Patients Receiving Neoadjuvant Chemotherapy for Gastric Cancer

for Gastric Adenocarcinoma

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07581405·Phase 2·Not Yet Recruiting

Defining the Ablative Dose for Y-90 TARE

for HCC - Hepatocellular Carcinoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07586046·Phase 2·Not Yet Recruiting

BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder

for Early-stage Breast Cancer

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18+

Code: NCT07596212·Phase 1, Phase 2·Not Yet Recruiting

A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

for Alzheimer Disease

Drug: Donanemab

52 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 55+

Code: NCT07602582·Phase 3·Not Yet Recruiting