Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines

Part of paid clinical trials in Chicago, Illinois.

Sponsor: Rush University Medical Center
Study ID: NCT07142369
Status: Not Yet Recruiting

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Conditions

Anterior Cruciate Ligament (ACL) Rupture
Posttraumatic Osteoarthritis

Eligibility Criteria

Sex: ALL
Age: 18 Years - 50 Years
Healthy Volunteers: Not accepted

Interventions

Synovial Fluid withdrawal at the preoperative clinic visit — PROCEDURE
Synovial Fluid withdrawal at the preoperative clinic visit
Platelet-Rich Plasma (PRP) preparation and injection — PROCEDURE
Platelet-Rich Plasma (PRP) preparation and injection
Synovial fluid withdrawal at the time of surgery — PROCEDURE
Synovial fluid withdrawal at the time of surgery
3mL synovial fluid withdrawn at the preoperative visit — PROCEDURE
3mL synovial fluid withdrawn at the preoperative visit

Study Details

The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.

Key Dates

Start date: May 31, 2026
Status verified: Feb 2026
Primary completion: Oct 31, 2028
Completion: Dec 31, 2028

Study Design

Enrollment: 99 participants (estimated)
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Arms

Active Comparator: Two Synovial Fluid Withdrawals
Subjects randomized to Arm 1 will have 2 synovial fluid withdrawals; one at the preoperative clinic visit and one at the time of surgery
Experimental: Platelet-Rich Plasma (PRP) and Two Synovial Fluid Withdrawals
Subjects randomized to ARM 2 will have 2 synovial fluid withdrawals one at the preoperative visit and one at the time of surgery. Platelet-Rich Plasma (PRP) preparation and injection will happen at the preoperative clinic visit.
Other: 3mL Synovial Fluid Withdrawal and Synovial Fluid Withdrawal at the Time of Surgery
Subjects randomized to Arm 3 will have 3mL withdrawal of synovial fluid at the preoperative visit and 1 synovial fluid withdrawal at the time of surgery

Primary Outcome Measure

Concentration of Collagen Type II Cytokine [ Time Frame: Enrollment up to surgery ]

Central Contacts

Adam Yanke, MD, PhD
(312) 432-2818
[email protected]
Jorge Chahla, MD, PhD
[email protected]

Locations (1)

Facility	City	State	ZIP	Site coordinators
Rush University Medical Center	Chicago	Illinois	60612	-

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By research site

Rush University Medical Center· Chicago, IL