Clinical Trials at Nationwide Children's Hospital

As of June 2026, 229 paid clinical trials are recruiting at Nationwide Children's Hospital, located at 700 CHILDRENS DR, COLUMBUS, OH 43205-2696, phone (614) 355-2103 in Columbus, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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229 clinical trials at Nationwide Children's Hospital

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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

59 locations incl. Birmingham

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting

Apply to this trial

MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

for Adamantinous Craniopharyngioma

5 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 39

Code: NCT05286788·Phase 2·Recruiting

Apply to this trial

Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)

for Sickle Cell Trait

10 locations incl. Birmingham

Sponsor: National Alliance for Sickle Cell Centers

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06071377·Recruiting

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A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

for High Grade Osteosarcoma

Drug: Cabozantinib

175 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 40

Code: NCT05691478·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

for Cancer Harboring BRAF Alterations

30 locations incl. Beverly Hills

Sponsor: Fore Biotherapeutics

Sex: All·Age: 10+

Code: NCT05503797·Phase 2·Recruiting

Apply to this trial

Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low Weight Infants

for Ductus Arteriosus, Patent

24 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 7 Days - 32 Days

Code: NCT05547165·Recruiting

Apply to this trial

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

101 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting

Apply to this trial

VR-PAT During Home Burn Dressings - Multisite

for Burns

2 locations incl. Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 6 - 17

Code: NCT05673551·Enrolling By Invitation

A Long-Term Follow-Up Study in Severe Hemophilia A Subjects Who Received BMN 270 in a Prior BioMarin Clinical Trial (270-401)

for Hemophilia A

13 locations incl. Los Angeles

Sponsor: BioMarin Pharmaceutical

Sex: Male·Age: 18+

Code: NCT05768386·Enrolling By Invitation

ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma

for Adamantinomatous Craniopharyngioma

8 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 39

Code: NCT05233397·Phase 2·Recruiting

Apply to this trial

Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients

for Hematopoietic Cell Transplant

27 locations incl. Birmingham

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: Up to 18

Code: NCT05550298·Recruiting

Apply to this trial

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

for High Grade Glioma

4 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 4 - 39

Code: NCT05278208·Phase 1, Phase 2·Recruiting

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A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

22 locations incl. South Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting

Apply to this trial

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

for Hematologic Malignancy

29 locations incl. Los Angeles

Sponsor: Therapeutic Advances in Childhood Leukemia Consortium

Sex: All·Age: 1 - 21

Code: NCT05476770·Phase 1·Recruiting

Apply to this trial

Randomized Trial on Mobile Technology and Young Drivers' Cellphone Use

for Cell Phone Use

1 location in Columbus

Sponsor: Motao Zhu

Sex: All·Age: 18 - 24·Accepts healthy volunteers

Code: NCT05163119·Recruiting

Apply to this trial

Targeting Adolescent Insomnia to Lessen Overall Risk of Suicidal Behavior

for Insomnia

1 location in Columbus

Sponsor: Jeff Bridge

Sex: All·Age: 11 - 18

Code: NCT05390918·Recruiting

Apply to this trial

Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

45 locations incl. Phoenix

Sponsor: PedAL BCU, LLC

Sex: All·Age: 29 Days - 21

Code: NCT05183035·Phase 3·Recruiting

Apply to this trial

Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

for Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection

22 locations incl. Birmingham

Sponsor: University of Calgary

Sex: All·Age: 9 Months - 21

Code: NCT05219110·Recruiting

Apply to this trial

NK Cells Infusions With Irinotecan, Temozolomide, and Dinutuximab

for Relapsed Neuroblastoma

Drug: Irinotecan

1 location in Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 29

Code: NCT04211675·Phase 1, Phase 2·Recruiting

Apply to this trial

A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum

for Suicidal Ideation

5 locations incl. Baltimore

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 12 - 99

Code: NCT05398250·Enrolling By Invitation

Investigation to Evaluate the Safety and Effectiveness of Cochlear Implantation in Children and Adults With Unilateral Hearing Loss/Single-sided Deafness

for Hearing Loss, Unilateral

8 locations incl. Palo Alto

Sponsor: Cochlear

Sex: All·Age: 5+

Code: NCT05318417·Recruiting

Apply to this trial

Pediatric Dose Optimization for Seizures in Emergency Medical Services

for Seizures

20 locations incl. Tucson

Sponsor: Stanford University

Sex: All·Age: 6 Months - 13

Code: NCT05121324·Phase 3·Recruiting

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

165 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting

Apply to this trial

The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

for Extubation Failure

17 locations incl. Little Rock

Sponsor: University of Pennsylvania

Sex: All·Age: 0 Days - 9 Weeks

Code: NCT05446272·Recruiting

Apply to this trial

Rett Syndrome Registry

for Rett Syndrome

18 locations incl. Birmingham

Sponsor: International Rett Syndrome Foundation

Sex: All·Age: 0 - 99

Code: NCT05432349·Recruiting

Apply to this trial

A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors

for Neuroblastoma

Drug: Cabozantinib

6 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 18 Months - 40

Code: NCT05135975·Phase 2·Recruiting

Apply to this trial

Genetically Engineered Cells (Anti-CD19/CD20/CD22 CAR T-cells) for the Treatment of Relapsed or Refractory Lymphoid Malignancies

for Recurrent Acute Lymphoblastic Leukemia

2 locations incl. Columbus

Sponsor: Sumithira Vasu

Sex: All·Age: 2+

Code: NCT05418088·Phase 1·Recruiting

Apply to this trial

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

for Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

32 locations incl. Birmingham

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 Day - 17

Code: NCT05267821·Phase 2, Phase 3·Recruiting

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A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

for Malignant Glioma

Drug: Selinexor

109 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 Months - 21

Code: NCT05099003·Phase 1, Phase 2·Recruiting

Apply to this trial

Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies

for Deep Venous Thrombosis

22 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: Up to 17

Code: NCT04924322·Phase 2, Phase 3·Recruiting

Apply to this trial

A-LiNK: Improving Outcomes in Autoimmune Liver Disease

for Autoimmune Hepatitis

8 locations incl. Palo Alto

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: All ages

Code: NCT05750498·Recruiting

Apply to this trial

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

164 locations incl. Birmingham

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting

Apply to this trial

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

219 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting

Apply to this trial

4D-710 in Adult Patients With Cystic Fibrosis

for Cystic Fibrosis Lung

20 locations incl. Birmingham

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 18+

Code: NCT05248230·Phase 2·Recruiting

Apply to this trial

Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL

for B-cell Acute Lymphoblastic Leukemia

20 locations incl. Los Angeles

Sponsor: Etan Orgel

Sex: All·Age: 10 - 25

Code: NCT05082519·Phase 2·Recruiting

Apply to this trial

Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children

for Respiratory Syncytial Virus Infections

15 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 3 Days - 2

Code: NCT05026749·Phase 3·Recruiting

Apply to this trial

Safety and Efficacy of Expanded, Universal Donor Natural Killer Cells for Relapsed/Refractory AML

for Acute Myeloid Leukemia

1 location in Columbus

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 24

Code: NCT05503134·Phase 1, Phase 2·Recruiting

Apply to this trial

Omega Tots Long Term Follow-up

for Preterm Birth

1 location in Columbus

Sponsor: Sarah Keim

Sex: All·Age: 8 - 10

Code: NCT05191823·Enrolling By Invitation

Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease

for Sickle Cell Disease

4 locations incl. Los Angeles

Sponsor: Kamau Therapeutics

Sex: All·Age: 12 - 40

Code: NCT04819841·Phase 1, Phase 2·Recruiting

Apply to this trial

Gene Therapy for IGHMBP2-Related Diseases

for SMARD1

1 location in Columbus

Sponsor: Megan Waldrop

Sex: All·Age: 2 Months - 14

Code: NCT05152823·Phase 1, Phase 2·Enrolling By Invitation