Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Conditions

• Metastatic Malignant Neoplasm in the Lung
• Metastatic Osteosarcoma
• Osteosarcoma

Eligibility Criteria

Sex

ALL

Age

N/A - 50 Years

Healthy Volunteers

Not accepted

Interventions

• Biospecimen Collection — PROCEDURE
  Undergo collection of tissue and blood
• Computed Tomography — PROCEDURE
  Undergo CT
• Questionnaire Administration — OTHER
  Ancillary studies
• Thoracoscopy — PROCEDURE
  Undergo video-assisted thoracoscopic surgery or VATS
• Thoracotomy — PROCEDURE
  Undergo open thoracic surgery

Study Details

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.

Key Dates

Start date

Apr 1, 2022

Status verified

Feb 2026

Primary completion

Mar 31, 2031

Completion

Mar 31, 2031

Study Design

Enrollment

62 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Arm A (thoracotomy)
  Patients undergo open thoracic surgery (thoracotomy). Patients undergo CT throughout the trial. Patients may also undergo collection of tissue on study and blood throughout the trial.
• Experimental: Arm B (thoracoscopy)
  Patients undergo thoracoscopy (video-assisted thoracoscopic surgery or VATS). Patients undergo CT throughout the trial. Patients may also undergo collection of tissue on study and blood throughout the trial.

Primary Outcome Measure

Thoracic event-free survival (tEFS) [ Time Frame: Four years after enrollment ]

Locations (219)

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