Heart disease Clinical Trials in Cleveland, OH

As of June 2026, 67 paid clinical trials are recruiting for Heart disease in Cleveland, Ohio. Heart disease research tests new drug therapies, device-based interventions, and lifestyle programs for heart failure, atrial fibrillation, hypertension, and coronary disease — including therapies that reduce hospitalization and cardiovascular death. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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67 clinical trials for Heart disease

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A SkeleTal Muscle Recovery Intervention With Dietary Protein in Heart Failure

for Heart Failure

2 locations incl. Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 18 - 100

Code: NCT05627440·Recruiting

Apply to this trial

Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

42 locations incl. Los Angeles

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting

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Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

for Heart Failure

1 location in Cleveland

Sponsor: NHS Greater Glasgow and Clyde

Sex: All·Age: 40+

Code: NCT05919342·Recruiting

Apply to this trial

Intracardiac Echocardiography Guided Watchman Device Implant

for Atrial Fibrillation

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06007872·Recruiting

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Continuation of the nuMoM2b Heart Health Study

for Cardiovascular Diseases

14 locations incl. Orange

Sponsor: RTI International

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05472597·Enrolling By Invitation

CV Imaging of Metabolic Interventions

for Bariatric Surgery Candidate

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05650307·Recruiting

Apply to this trial

Development of CIRC Technologies

for Cardiovascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05654272·Recruiting

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AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

for Heart Failure

37 locations incl. Fairhope

Sponsor: Cordio Medical

Sex: All·Age: 22+

Code: NCT06378632·Recruiting

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Assessment of CCM in HF With Higher Ejection Fraction

for Heart Failure

105 locations incl. Birmingham

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT05064709·Recruiting

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Novel Clinical Utility of Retinal Imaging in Patients With Heart Failure

for Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05086978·Enrolling By Invitation

Vascular Events In Patients Undergoing Same-day Noncardiac Surgery (VALIANCE) Study

for Preoperative Care

5 locations incl. Winston-Salem

Sponsor: Centre hospitalier de l'Université de Montréal (CHUM)

Sex: All·Age: 45+

Code: NCT04973397·Recruiting

Apply to this trial

The GUARDIAN Trial

for Blood Pressure

6 locations incl. Omaha

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 45+

Code: NCT04884802·Recruiting

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The GUARDIAN Trial - Vasopressor Sub-Study

for Blood Pressure

4 locations incl. Omaha

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 45+

Code: NCT04934748·Phase 4·Enrolling By Invitation

Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

for Coronary Artery Disease

40 locations incl. Birmingham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT04451044·Enrolling By Invitation

OPtimizing Technology to Improve Medication Adherence and BP Control (OPTIMA-BP)

for Hypertension

1 location in Cleveland

Sponsor: Case Western Reserve University

Sex: All·Age: 50+

Code: NCT05293756·Recruiting

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

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Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

Apply to this trial

Vascular Lab Resource (VLR) Biorepository

for Cardiovascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05628948·Recruiting

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ATrial Tachycardia PAcing Therapy in Congenital Heart

for Atrial Arrhythmia

14 locations incl. Los Angeles

Sponsor: Ian Law

Sex: All·Age: All ages

Code: NCT03209583·Recruiting

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Randomization of Single vs Multiple Arterial Grafts

for Coronary Artery Disease

11 locations incl. Boulder

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 70

Code: NCT03217006·Recruiting

Apply to this trial

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

75 locations incl. Gilbert

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting

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The Oxford Risk Factors And Non-Invasive Imaging Study

for Cardiovascular Diseases

3 locations incl. Bethesda

Sponsor: University of Oxford

Sex: All·Age: 18 - 99

Code: NCT05169333·Recruiting

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Tracking Results of Ablations to Combat AF Registry Generation 2

for Atrial Fibrillation

26 locations incl. Huntsville

Sponsor: AtriCure, Inc.

Sex: All·Age: 18+

Code: NCT05111015·Recruiting

Apply to this trial

Product Surveillance Registry

for Cardiac Rhythm Disorders

134 locations incl. Birmingham

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT01524276·Recruiting

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Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

for Arrhythmia

113 locations incl. Birmingham

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT00271180·Recruiting

Apply to this trial

Conditions in Heart disease (Cleveland, OH)

Heart failure· 24 Cardiovascular disease (general)· 19 Atrial fibrillation· 15 Coronary artery disease· 12 Hypertension (high blood pressure)· 6 Congenital heart disease· 3 Myocardial infarction (heart attack)· 1