The Oxford Risk Factors And Non-Invasive Imaging Study

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
University of Oxford
Study ID
NCT05169333
Status
Recruiting
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Conditions

  • Cardiovascular Diseases
  • Cardiovascular Risk Factors

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

ORFAN is a prospective, multi-centre, multi-ethnic cohort observational study collecting CT scans, biological material and outcomes data, to develop and validate novel biomarkers of cardiometabolic and other disease risk.

Key Dates

Start date
Feb 23, 2016
Status verified
Dec 2024
Primary completion
Feb 28, 2030
Completion
Feb 28, 2030

Study Design

Enrollment
250,000 participants (estimated)

Arms

  • Arm: Group 1
    Participants attending cardiology department, hypertension or outpatient clinics.
  • Arm: Group 2
    Participants who are recruited prospectively, during their clinically indicated CT scan, and they are followed-up prospectively for clinical endpoints; A follow-up CCTA at least 6 months later will be offered to a subgroup of these patients, to assess disease progression.
  • Arm: Group 3
    Individuals where at least 6 months have elapsed from previous CCTA will undergo repeat CCTA scan and enter prospective follow up for clinical endpoints.
  • Arm: Group 4
    Cohort of consecutive patients who have undergone clinical CTAs or unenhanced CT chest, abdomen and pelvis in the past, linking the index CT scan with prospective outcomes collection already accumulated.

Primary Outcome Measure

Cardiac and all cause mortality [ Time Frame: 15 years ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
NIH National Heart, Lunch, and Blood InstituteBethesdaMaryland--
Mayo ClinicRochesterMinnesota--
Cleveland Clinic Heart and Vascular InstituteClevelandOhio--

Find similar trials in Bethesda, MD

By research site
NIH National Heart, Lunch, and Blood Institute· Bethesda, MDMayo Clinic· Rochester, MNCleveland Clinic Heart and Vascular Institute· Cleveland, OH

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