Development of CIRC Technologies

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
The Cleveland Clinic
Study ID
NCT05654272
Status
Recruiting
Apply to this trial

Conditions

  • Aortic Diseases
  • Atrial Fibrillation
  • Cardiovascular Diseases
  • Congenital Heart Disease
  • Heart Failure
  • Ischemic Heart Disease
  • Metabolic Cardiomyopathy
  • Non-ischemic Cardiomyopathy
  • Valvular Heart Disease
  • Ventricular Fibrillation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • MRI — DIAGNOSTIC_TEST
    Cardiac MRI

Study Details

Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization. Moreover, the intrinsic advantage of MRI's lack of exposure to ionizing radiation is particularly beneficial. At the same time, blood work can be very useful in early detection of certain cardiomyopathy, such as amyloid. However, there is a lack of agreement of on which markers are the most sensitive. This multi-study will allow us the unique opportunity to form a more comprehensive understanding for various cardiovascular diseases. Our team has developed novel cardiac MRI techniques that leverages endogenous tissue properties to reveal a milieu of deep tissue phenotypes including myocardial inflammation, fibrosis, metabolism, and microstructural defects. Among these phenotypes, myocardial microstructure has proven to be most sensitive to early myocardial tissue damage and is predictive of myocardial regeneration. In this study, the investigators aim to further study the importance of cardiac microstructure revealed by MRI in patient and healthy population and compare this novel technology with conventional clinical biomarkers.

Key Dates

Start date
Sep 9, 2022
Status verified
Apr 2026
Primary completion
Sep 9, 2032
Completion
Sep 9, 2042

Study Design

Enrollment
1,000 participants (estimated)

Arms

  • Arm: Normal
    Normal volunteers \>=18 years older
  • Arm: Cardiovascular Disease Patient
    \>=18years older with known prior cardiovascular disease

Primary Outcome Measure

Myocardial Microstructure (Helix Angle) via Next Generation Cardiac MRI [ Time Frame: 20 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cardiovascular Innovation Research CenterClevelandOhio44195
Lily Chen
[email protected]
216-445-8561
Christopher Nguyen, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Cleveland, OH

By condition
Atrial fibrillationHeart failure
By specialty
CardiologyHeart disease
By research site
Cardiovascular Innovation Research Center· Cleveland, OH

Related Studies