Novel Clinical Utility of Retinal Imaging in Patients With Heart Failure

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
The Cleveland Clinic
Study ID
NCT05086978
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

Endothelial dysfunction and microvascular disease have been shown to play an important role in both the development and progression of heart failure. Retinal imaging provides a unique opportunity to non-invasively assess retinal microcirculation. Leveraging the non-invasiveness and relative ease of use of retinal imaging, we propose to investigate its clinical utility in assessing endothelial/microvascular dysfunction across the spectrum of heart failure. We aim to test the hypothesis that the degree of abnormality in retinal vessels is associated with heart failure disease severity, endothelial/microvascular dysfunction, and, potentially, treatment responses.

Key Dates

Start date
Feb 1, 2022
Status verified
Jan 2026
Primary completion
Jul 1, 2026
Completion
Jan 1, 2027

Study Design

Enrollment
250 participants (estimated)

Arms

  • Arm: Heart Failure out-patients
    Subjects with heart failure of any etiology
  • Arm: Heart Failure in-patients
    Subjects with heart failure of any etiology

Primary Outcome Measure

Retinal measurements and heart failure severity [ Time Frame: 4 years ]

Locations (1)

FacilityCityStateZIPSite coordinators
Cleveland ClinicClevelandOhio44195-

Find similar trials in Cleveland, OH

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
Cleveland Clinic· Cleveland, OH

Related Studies