Behavioral health Clinical Trials in Charleston, SC

As of June 2026, 69 paid clinical trials are recruiting for Behavioral health in Charleston, South Carolina. Behavioral health trials span mental-health pharmacotherapy and addiction treatment — testing new agents and therapies for depression, anxiety, opioid use disorder, alcohol use, and tobacco cessation. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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Healthy volunteers only

69 clinical trials for Behavioral health

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Switch or Quit R01

for Cigarette Smoking

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06373679·Recruiting

Apply to this trial

QL vs LAI for Palatoplasty

for Post-operative Pain

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 6 - 18

Code: NCT06420336·Recruiting

Apply to this trial

Transcranial Magnetic Stimulation for MCI

for Mild Cognitive Impairment

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 60 - 85

Code: NCT05992831·Recruiting

Apply to this trial

Modulating Escape Using Focused Ultrasound

for Anxiety Disorders

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT06273904·Recruiting

Apply to this trial

Cultural Adaptation of Drug Treatment for DJJ Youth

for Substance Use

2 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 13 - 17·Accepts healthy volunteers

Code: NCT06003725·Recruiting

Apply to this trial

Young Adult Tobacco/Nicotine and Cannabis Co-use

for Tobacco Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 25·Accepts healthy volunteers

Code: NCT06239350·Recruiting

Apply to this trial

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

for Posttraumatic Stress Disorder

2 locations incl. Charleston

Sponsor: Texas A&M University

Sex: All·Age: 18+

Code: NCT05959434·Phase 2·Recruiting

Apply to this trial

A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

for Cigarette Smoking

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06118502·Recruiting

Apply to this trial

Rural COPD E-Visit Study

for Smoking Cessation

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT06236347·Enrolling By Invitation

Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship

for Alcohol Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT05786157·Recruiting

Apply to this trial

RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

for Healthy

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05977439·Recruiting

Apply to this trial

RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS

for Epilepsy

5 locations incl. Stanford

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT06143293·Recruiting

Apply to this trial

SCORE Emerging Adult Cannabis Use & Stress

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 25

Code: NCT05885542·Phase 1, Phase 2·Recruiting

Apply to this trial

taVNS or TMS or Both for Depression

for Depression

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 75

Code: NCT05725239·Recruiting

Apply to this trial

Brief Family Involved Treatment Telehealth

for Alcohol Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT05674409·Recruiting

Apply to this trial

Investigating Novel Smoking Cessation Primary Care Interventions in Rural Environments

for Smoking Cessation

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05764759·Recruiting

Apply to this trial

CARS: Cannabis and Alcohol Reduction Study

for Cannabis Use

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 13 - 17

Code: NCT05486234·Recruiting

Apply to this trial

CRP and S&A for Inpatient Veterans

for Alcoholism

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT05054738·Recruiting

Apply to this trial

Enhancing Smoking Cessation Via Telehealth Options in Primary Care

for Smoking Cessation

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05493254·Recruiting

Apply to this trial

Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors

for Traumatic Injury

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 12 - 17·Accepts healthy volunteers

Code: NCT05086757·Recruiting

Apply to this trial

Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders

for Bipolar Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT05064319·Phase 2·Recruiting

Apply to this trial

Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care

for Depression

1 location in Charleston

Sponsor: VA Office of Research and Development

Sex: All·Age: 21+

Code: NCT04877197·Phase 3·Recruiting

Apply to this trial

Low-Intensity Focused Ultrasound Pulsation (LIFUP) for the Treatment of Generalized Anxiety Disorder (GAD)

for Generalized Anxiety Disorder

3 locations incl. Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 65

Code: NCT04557891·Recruiting

Apply to this trial

MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience

for Alcohol Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21 - 65

Code: NCT04998916·Recruiting

Apply to this trial

Modulating Anxious Coping

for Anxiety Disorders

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18 - 65

Code: NCT04824105·Recruiting

Apply to this trial

RTMS Targets Neural Circuits for Smoking Cessation

for Tobacco Use

2 locations incl. Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 22 - 70·Accepts healthy volunteers

Code: NCT04903028·Recruiting

Apply to this trial

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

for Coronavirus Infection (COVID-19)

49 locations incl. Phoenix

Sponsor: Duke University

Sex: All·Age: 0 - 20·Accepts healthy volunteers

Code: NCT04278404·Recruiting

Apply to this trial

Smoking Cessation Behavioral Treatment Study

for Tobacco Use Disorder

2 locations incl. Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03948893·Recruiting

Apply to this trial

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

for Treatment Resistant Depression

98 locations incl. Birmingham

Sponsor: LivaNova

Sex: All·Age: 18+

Code: NCT03887715·Recruiting

Apply to this trial

Conditions in Behavioral health (Charleston, SC)

Depression· 19 Tobacco / nicotine use· 15 PTSD (post-traumatic stress disorder)· 13 Opioid use disorder· 7 Substance use disorder· 7 Cannabis use / cannabis use disorder· 7 Anxiety· 5 Alcohol use disorder· 5 ADHD· 2 Bipolar disorder· 1