RTMS Targets Neural Circuits for Smoking Cessation

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT04903028
Status
Recruiting
Apply to this trial

Conditions

  • Cigarette Smoking
  • Tobacco Use

Eligibility Criteria

Sex
ALL
Age
22 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Sham rTMS — DEVICE
    Two electrodes on the scalp will be connected to transcutaneous electrical nerve stimulation.
  • Active rTMS 10 Hz DLPFC — DEVICE
    10 Hz repetitive transcranial magnetic stimulation (rTMS) will be delivered over left dorsolateral prefrontal cortex (DLPFC).

Study Details

Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel, non-pharmacological interventions for depression and cigarette smokers. In this study, investigators will use brain MRI to guide TMS therapy for smoking cessation.

Key Dates

Start date
May 15, 2021
Status verified
Apr 2026
Primary completion
Feb 28, 2027
Completion
Apr 4, 2027

Study Design

Enrollment
64 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Sham Comparator: Sham rTMS
    Investigators will use electrode stimulation with 10 Hz over DLPFC, total 3000 pulses. The sham-TMS scalp discomfort was matched to that of active TMS. During real TMS there was no current flowing through the scalp electrodes.
  • Active Comparator: Active rTMS 10 Hz DLPFC
    A stimulation frequency of 10 Hz, pulse train duration (on time) of 5 seconds, inter-train interval (off time) of 10 seconds (15 second cycle time), E-field-modeling to determine TMS intensity and coil orientation, total of 60 trains, session time of 15 minutes, and 3000-total pulses per day, will be delivered over the left DLPFC.

Primary Outcome Measure

4 week continue quit rate [ Time Frame: 20 weeks ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29425
Xingbao Li, M.D
[email protected]
843 7925729
Xingbao Li, M.D (PRINCIPAL_INVESTIGATOR)
Medical University of South CarolinaCharlestonSouth Carolina29425
Xingbao Li, MD, MSCR, MS
[email protected]
843-792-5729
Rebecca Keneally
[email protected]
843-792-0136

Find similar trials in Charleston, SC

By research site
Medical University of South Carolina· Charleston, SC

Related Studies