Heart disease Clinical Trials in Boston, MA

As of June 2026, 120 paid clinical trials are recruiting for Heart disease in Boston, Massachusetts. Heart disease research tests new drug therapies, device-based interventions, and lifestyle programs for heart failure, atrial fibrillation, hypertension, and coronary disease — including therapies that reduce hospitalization and cardiovascular death. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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120 clinical trials for Heart disease

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Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0

for Acute Kidney Injury

50 locations incl. Birmingham

Sponsor: Indiana University

Sex: All·Age: 0 Minutes - 2 Weeks

Code: NCT06823115·Enrolling By Invitation

Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

for PTSD

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07260032·Recruiting

Apply to this trial

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

for Heart Failure

88 locations incl. Alexander City

Sponsor: Cytokinetics

Sex: All·Age: 18 - 85

Code: NCT06736574·Phase 3·Recruiting

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Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

for Heart Failure

57 locations incl. Phoenix

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT06526195·Recruiting

Apply to this trial

Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children

for Congenital Heart Disease

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 1 Day - 12

Code: NCT05687292·Recruiting

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Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

for Heart Failure

6 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06517186·Recruiting

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Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

for Cardiovascular Diseases

2 locations incl. Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06244199·Recruiting

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Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

for Diabetic Nephropathies

Drug: Sotagliflozin

13 locations incl. Stanford

Sponsor: Alessandro Doria

Sex: All·Age: 18 - 75

Code: NCT06217302·Phase 3·Recruiting

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Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis

for Congenital Heart Disease

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 1 Day - 7 Days

Code: NCT06434207·Recruiting

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Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

for Cardiovascular Diseases

37 locations incl. Little Rock

Sponsor: BrioHealth Solutions, Inc.

Sex: All·Age: 18 - 100

Code: NCT06310031·Recruiting

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Care Transitions App for Patients With Multiple Chronic Conditions

for Heart Failure

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06051058·Recruiting

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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399705·Phase 3·Recruiting

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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399692·Phase 3·Recruiting

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A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

for Pulmonary Hypertension

31 locations incl. Phoenix

Sponsor: Tectonic Therapeutic

Sex: All·Age: 18 - 83

Code: NCT06616974·Phase 2·Recruiting

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PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

for Coronary Artery Disease

18 locations incl. Chandler

Sponsor: Kardion Inc

Sex: All·Age: 18 - 90

Code: NCT06445608·Recruiting

Apply to this trial

AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention

for Coronary Artery Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 75

Code: NCT06235112·Recruiting

Apply to this trial

Lumason® Infusion vs. Bolus Administrations

for Heart Diseases

6 locations incl. West Hills

Sponsor: Bracco Diagnostics, Inc

Sex: All·Age: 18+

Code: NCT06400004·Phase 3·Recruiting

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Study to Determine the Clinical Significance of Intravascular OCT-NIRAF

for Cardiovascular Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06374498·Enrolling By Invitation

Global Paradise System US Post Approval Study

for Hypertension

39 locations incl. Sacramento

Sponsor: ReCor Medical, Inc.

Sex: All·Age: 18+

Code: NCT06297291·Recruiting

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A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)

for Atrial Fibrillation

43 locations incl. Phoenix

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT06455098·Recruiting

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A Multi-center, National, Open-label, Prospective Study to Evaluate the Performance of the V-Lap™ System

for Heart Failure

1 location in Boston

Sponsor: Vectorious Medical Technologies Ltd.

Sex: All·Age: 22 - 88

Code: NCT06147336·Recruiting

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A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF

for Atrial Fibrillation

35 locations incl. Birmingham

Sponsor: Heart Rhythm Clinical and Research Solutions, LLC

Sex: All·Age: 18+

Code: NCT06335082·Enrolling By Invitation

MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions

for In-Stent Restenosis

28 locations incl. Birmingham

Sponsor: Concept Medical Inc.

Sex: All·Age: 18 - 110

Code: NCT05908331·Recruiting

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PRESSURE CHECK: Find Your Path to Better Health

for Blood Pressure

4 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT06122246·Recruiting

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The STOP-MED CTRCD Trial

for Heart Failure

2 locations incl. Los Angeles

Sponsor: Dinesh Thavendiranathan

Sex: All·Age: 18+

Code: NCT06183437·Phase 4·Recruiting

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Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

for Group 2 Pulmonary Hypertension

8 locations incl. Chicago

Sponsor: Gradient Denervation Technologies

Sex: All·Age: 22 - 85

Code: NCT06052072·Enrolling By Invitation

Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure

for Heart Failure

1 location in Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 18 - 100

Code: NCT06253104·Recruiting

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CV CARE: CardioVascular Care in PC Patients

for Prostate Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Male·Age: 18+

Code: NCT06202820·Recruiting

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A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

for Heart Failure

Drug: Finerenone

77 locations incl. Birmingham

Sponsor: Colorado Prevention Center

Sex: All·Age: 18+

Code: NCT06008197·Phase 3·Recruiting

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BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

for Hypertension

70 locations incl. Scottsdale

Sponsor: Orchestra BioMed, Inc

Sex: All·Age: 18+

Code: NCT06059638·Recruiting

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Safety and Effectiveness of Pulmonary Vein isOLation And posterioR Wall Ablation wIth pulSed Field Energy in Patients With Paroxysmal and Persistent AF

for Atrial Fibrillation

6 locations incl. Jonesboro

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06099730·Recruiting

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Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Change in Cardiovascular Health

for Coronary Artery Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 75

Code: NCT05819814·Recruiting

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Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine

for Coronary Artery Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 40 - 75

Code: NCT05850091·Phase 4·Recruiting

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PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

for Heart Failure NYHA Class II

47 locations incl. Phoenix

Sponsor: Endotronix, Inc.

Sex: All·Age: 18+

Code: NCT05934487·Recruiting

Apply to this trial

SELUTION 4 De Novo Small Vessel IDE Trial

for Coronary Artery Disease

43 locations incl. Jonesboro

Sponsor: M.A. Med Alliance S.A.

Sex: All·Age: 18+

Code: NCT05946629·Recruiting

Apply to this trial

CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

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Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension

for Hypertension

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT05593055·Phase 4·Recruiting

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The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

93 locations incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting

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Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

for Heart Failure

20 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 29 Days - 17

Code: NCT05714085·Phase 2, Phase 3·Recruiting

Apply to this trial

Conditions in Heart disease (Boston, MA)

Heart failure· 42 Cardiovascular disease (general)· 28 Hypertension (high blood pressure)· 20 Atrial fibrillation· 20 Coronary artery disease· 17 Congenital heart disease· 9 Myocardial infarction (heart attack)· 1