RecruitingPhase 4Drug trialPolygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and ColchicineThe goal of this double-blind randomized controlled trial is to determine how treatment with high intensity statin, low-dose colchicine, and their combination modulates progression and composition of coronary atherosclerosis in individuals with high polygenic risk for coronary artery disease.