Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Northwestern University
Study ID
NCT06517186
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
30 Years - N/A
Healthy Volunteers
Accepted

Study Details

The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new treatments for heart failure.

Key Dates

Start date
Nov 8, 2024
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
180 participants (estimated)

Arms

  • Arm: HFpEF
    Participants with HFpEF
  • Arm: Non-HFpEF
    Participants without HFpEF

Primary Outcome Measure

Number of participants with Heart Failure with Preserved Ejection Fraction (HFpEF) [ Time Frame: Up to 5 years ]

Central Contacts

Locations (6)

FacilityCityStateZIPSite coordinators
Northwestern UniversityChicagoIllinois60611
Laura Alagna
[email protected]
312-695-6765
Sadiya Khan, MD (PRINCIPAL_INVESTIGATOR)
Laura Rasussen-Torvik, PhD, MPH (PRINCIPAL_INVESTIGATOR)
Johns Hopkins UniversityBaltimoreMaryland21287
Matt Kauffman
[email protected]
Kavita Sharma, MD (PRINCIPAL_INVESTIGATOR)
David Kass, MD (SUB_INVESTIGATOR)
Mass General BrighamBostonMassachusetts02114
Diane Cocca-Spofford
[email protected]
617-726-8228
Greg Lewis, MD (PRINCIPAL_INVESTIGATOR)
Akshay Desai, MD, MPH (SUB_INVESTIGATOR)
Michael Givertz, MD (SUB_INVESTIGATOR)
Scott Solomon, MD (SUB_INVESTIGATOR)
Mayo ClinicRochesterMinnesota55905
Brendon Urena
[email protected]
507-538-8305
Margaret Redfield, MD (PRINCIPAL_INVESTIGATOR)
Borlaug Barry, MD (SUB_INVESTIGATOR)
Wake Forest UniversityWinston-SalemNorth Carolina27157
Ben Nelson
336-716-6789
Dalane Kitzman, MD (PRINCIPAL_INVESTIGATOR)
Alain Bertoni, MD, MPH (SUB_INVESTIGATOR)
University of PennsylvaniaPhiladelphiaPennsylvania19104
Tiffany Sharkoski
215-615-2354
Julio Chirinos, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Chicago, IL

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
Northwestern University· Chicago, ILJohns Hopkins University· Baltimore, MDMass General Brigham· Boston, MAMayo Clinic· Rochester, MNWake Forest University· Winston-Salem, NCUniversity of Pennsylvania· Philadelphia, PA

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